Analysis of the Effects of Concentrated Autologous Growth Factor on the Efficacy,Gingival Thickness,and Immune Factor Levels of Periodontal Tissue Regeneration Surgery in Patients with Severe Periodontitis
Objective:To explore the therapeutic effect of concentrated autologous growth factor combined with periodontal tissue regeneration on patients with severe periodontitis,as well as the effects of gingival thickness and immune factor levels.Methods:A prospective study was conducted on 58 patients with severe periodontitis admitted to our hospital from June 2019 to June 2020.They were divided into a matched group and an observation group using a random number table method,with 29 patients in each group.The matched group received periodontal tissue regeneration surgery;The observation group received periodontal tissue regeneration surgery combined with concentrated autologous growth factor treatment.Prior to treatment and 9 months Post-treatment,follow-up visits were conducted to compare the clinical efficacy of the two groups of patients,including gingival thickness,visual analog scale(VAS)scores,and the expression levels of interleukin-17(IL-17),interleukin-23(IL-23),and interleukin-17(IL-23)in gingival crevicular fluid and serum before and Post-treatment.Results:The total effective rate of 93.10％in the observation group was higher than 72.41％in the matched group(P＜0.05);Pretherapy,there was no difference in gingival thickness and VAS score between the two groups of patients(P＞0.05).Post-treatment,the gingival thickness of the two groups of patients increased,and the observation group was higher than the matched group,while the VAS score decreased.The observation group was lower than the matched group(P＜0.05);Pretherapy,there was no dif-ference in the comparison of gingival crevicular fluid IL-17,IL-23,and IL-10 between the two groups(P＞0.05).Post-treatment,the ex-pression of gingival crevicular fluid factor was different between the two groups of patients,and the observation group was different com-pared with the matched group(P＜0.05);Pretherapy,there was no difference in serum IL-17,IL-23,and IL-10 comparison(P＞0.05).Post-treatment,the serum factor expression between the two groups was different,and the observation group was different compared with the matched group(P＜0.05).Conclusion:The combination of concentrated autologous growth factor and periodontal tissue regeneration has a significant therapeutic effect on severe periodontitis.It can increase the thickness of the patient's gingiva,reduce pain,improve the levels of immune factors in gingival crevicular fluid and serum,and reduce inflammatory reactions.It is worthy of clinical application and promotion.
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