Expression Levels of Serum Galectin-10 and Inflammatory Factors in Children with Atopic Dermatitis of Different Severity and Their Correlation with Skin Infection
Objective:To analyze the expression levels of serum galectin-10(Gal-10)and inflammatory factors and their correla-tion with skin infection in children with atopic dermatitis of different severity.Methods:A total of 110 children with atopic dermatitis ad-mitted to our hospital from January 2022 to January 2023 were included in the observation group.They were divided into mild group,moderate group and severe group according to SCORAD.Another 110 healthy children were included in the control group.The levels of serum Gal-10,inflammatory factors(IL-4,IL-13,IL-31)and percutaneous water loss in different parts of the skin were detected,and the relationship between serum Gal-10,IL-4,IL-13,IL-31,SCORAD score and percutaneous water loss in different parts of the skin was analyzed.The predictive efficacy of serum Gal-10 and inflammatory factors(IL-4,IL-13,IL-31)on skin infection was analyzed using receiver operating characteristic curve(ROC).Results:The levels of serum Gal-10,IL-4,IL-13 and IL-31 in observation group were higher than those in control group(P＜0.05).With the aggravation of atopic dermatitis in children,serum levels of Gal-10,IL-4,IL-13 and IL-31 increased,and serum levels of Gal-10,IL-4,IL-13 and IL-31 in mild,moderate and severe groups were significantly different(P＜0.05).By Pearson correlation analysis,serum Gal-10,IL-4,IL-13 and IL-31 levels were positively correlated with SCORAD score,and percuta-neous water loss in anterior wall extension,anterior wall flexion,cheek and anterior tibia in atopic dermatitis children(P＜0.05).Among 110 children with atopic dermatitis,43 had skin infections.According to ROC curve analysis,the sensitivity of serum Gal-10,IL-4,IL-13 combined with IL-31 to predict skin infection in children with atopic dermatitis was 89.72％,the specificity was 56.97％and the area un-der ROC curve(AUC)was 0.921.Conclusion:The levels of serum Gal-10 and inflammatory factors(IL-4,IL-13,IL-31)are significantly correlated with the severity of atopic dermatitis in children,and are of certain significance in evaluating skin barrier function and predict-ing skin infection,which is worthy of clinical attention.
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