Different Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease FIB,RDW,MDW and Expression Level of IL-6 and Lung Function,Correlation Analysis of Acute Episodes
Objective:To analyse the different degrees of chronic obstructive pulmonary disease(COPD)patients with serum fib-rinogen(FIB),red blood cell distribution width(RDW)and mononuclear cell volume distribution width(MDW)and the expression of in-terleukin 6(IL-6)level and its correlation with pulmonary function,acute attack.Methods:Select our hospital from April 2021 to April 2023 accepts 148 COPD patients in observation group,according to the current severity limited is divided into light,moderate current limited group(96 cases)and heavy-very severely limited airflow group(52 cases).Work in the same period of 148 cases of healthy physical examination in the control group.Test all entrants FIB,RDW,MDW and serum IL-6 expression level,comparison between dif-ferent groups of serum FIB,RDW,MDW and the expression of IL-6 level.Using Pearson correlation analysis of serum FIB,RDW,MDW and IL-6 and lung function index[the first second forced expiratory volume and forced vital capacity(FEV1/FVC)take up of the expected value and the first second forced expiratory volume percentage of expected Mr Pred(FEV1％)].ROC curve analysis of serum FIB,RDW,MDW and IL-6 prediction of acute episodes.Results:Observation group serum FIB,RDW,MDW and the expression of IL-6 levels are higher than the control group(P＜0.05).Heavy-very severely limited airflow group serum FIB,RDW,MDW and the expression of IL-6 levels were higher than light to moderate limited airflow group(P＜0.05).The Pearson correlation analysis,COPD patients serum FIB,RDW,MDW and the expression of IL-6 level and FEV1/FVC take up of the expected value,negatively correlated with both FEV1％Mr Pred(P＜0.05).The ROC curve analysis,FIB,RDW,serum IL-6 MDW combined predictions COPD acute sensitivity of 66.35％,90.42％,AUC is 0.912.Conclusion:COPD patients with different level of serum FIB,RDW,MDW differences and the expression of IL-6 level,serum FIB,RDW,MDW and IL-6 contact closely with the pulmonary function,combined with certain predictive value of acute attack.
Chronic obstructive pulmonary diseaseFibrinogenErythrocyte distribution widthMonocyte volume distribution widthInterleukin 6
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