Analysis of the Expression of Inflammatory Factors and TSP-1 in Gingival Crevicular Fluid in Orthodontic Patients Undergoing Tooth Extraction and the Influencing Factors of Periodontal Disease Occurrence
Objective:To explore the expression of inflammatory factors and TSP-1 in gingival crevicular fluid in patients under-going orthodontic extraction,and the influencing factors of periodontal disease.Methods:Eighty patients admitted to our hospital from August 2020 to August 2023 for orthodontic treatment of extracted teeth were retrospectively analyzed,and gingival sulcus fluid samples were taken from all the patients before orthodontic treatment,1 month after orthodontic treatment,3 months after orthodontic treatment,and at the end of orthodontic treatment to detect the tumor necrosis factor-alpha(TNF-alpha),interleukin-1 beta(IL-1beta),interleukin-6(IL-6),and platelet reactive protein-1(TSP-1)expression levels.Subsequently,the patients were divided into periodontal disease group(n=36)and non-periodontal disease group(n=44)according to whether they suffered from periodontal disease during orthodontic treat-ment,compared the expression levels of TNF-α,IL-1β,IL-6,and TSP-1 of the patients in the two groups before orthodontic treatment and at the end of orthodontic treatment,and compared the general conditions of the patients in the two groups,and then analyzed the in-fluence factors of periodontal diseases in patients with extracted teeth in orthodontics with the use of logistic regression model.Disease Influencing Factors.Results:TNF-α,IL-1β,IL-6,and TSP-1 levels were elevated at 1 month and 3 months after orthodontic treatment in 80 patients with extracted teeth,and TNF-α,IL-1β,IL-6,and TSP-1 levels leveled off from 3 months to the end of orthodontic treatment,but were significantly higher than those before orthodontic treatment at 1 month,3 months,and at the end of orthodontic treatment(P＜0.05);there were significant differences in the expression levels of TNF-α,IL-1β,IL-6,and TSP-1 in patients in the periodontal diseases group compared to those in the non periodontal diseases group,and the expression levels in the periodontal diseases group were significantly higher than those in the non periodontal diseases group(P＜0.05).There were significant differences in the expression levels of TNF-α,IL-1β,IL-6,and TSP-1 between patients in the pre-orthodontic and post-orthodontic groups,and the periodontal disease group was sig-nificantly higher than the non-periodontal disease group(P＜0.05);there were no significant differences in the comparison of gender,age,and BMI between patients in the periodontal disease group and the non-periodontal disease group(P＞0.05),and there were no significant differences in the duration of orthodontic treatment,number of extractions,oral cavity,oral cavity,and oral health of patients in the peri-odontal disease group and the non-periodontal disease group(P＜0.05).number,orthodontic method,and oral cleanliness were compared significantly(P＜0.05);logistic regression analysis showed that TNF-α,IL-1β,IL-6,TSP-1,orthodontic method,and oral cleanliness were independent risk factors for periodontal disease in patients with extracted teeth and orthodontic treatment(P＜0.05).Conclusion:Inflam-matory factors of gingival crevicular fluid and TSP-1 levels increased significantly in orthodontic patients with prolonged orthodontic time,and TNF-α,IL-1 β,IL-6,TSP-1,orthodontic mode and oral cleanliness were independent risk factors for periodontal disease in or-thodontic patients.
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