Study on the Relationship between Aqueous Humor Sema3A,Klotho,SDF-1 and Postoperative Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy
Objective:To investigate the relationship between aqueous humor semaphorin-3A(Sema3A),Klotho,stromal cell-de-rived factor-1(SDF-1)and postoperative neovascular glaucoma(NVG)in patients with proliferative diabetic retinopathy(PDR).Methods:145 patients admitted to Chengdu Sixth People's Hospital from January 2021 to January 2022 who underwent vitrectomy PDR were se-lected,and according to whether occurrence of NVG at 1 year after surgery,patients were divided into the NVG group and the non-NVG group.Enzyme-linked immunosorbent assay was used to detect the levels of aqueous humor Sema3A,Klotho and SDF-1.Multivariate Logistic regression analysis was used to analyze the factors affecting postoperative NVG in patients with PDR,and the predictive value of aqueous humor Sema3A,Klotho and SDF-1 on postoperative NVG in patients with PDR was analyzed by receiver operating characteris-tic(ROC)curve.Results:PDR patients were followed up for 1 year,and the incidence rate of postoperative NVG was 17.24％.Compared with the non-NVG group,the levels of aqueous humor Sema3A and SDF-1 in the NVG group were increased,and the level of Klotho was decreased(P＜0.05).Multivariate Logistic regression analysis showed that preoperative iris neovascularization and elevated Sema3A and SDF-1 were independent risk factors affecting postoperative NVG in patients with PDR,and elevated Klotho was an independent protective factor(P＜0.05).ROC curve analysis showed that the area under curve(AUC)of aqueous humor Sema3A,Klotho and SDF-1 predicted postoperative NVG in patients with PDR was 0.913,which was greater than the 0.796,0.794,and 0.800 predicted by aqueous humor Sema3A,Klotho and SDF-1 individually.Conclusion:Elevated aqueous humor Sema3A,SDF-1 and reduced Klotho are closely related to the occurrence of postoperative NVG in patients with PDR,and the combined detection of aqueous humor Sema3A,Klotho and SDF-1 has a high predictive value for postoperative NVG in patients with PDR.
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