Effects of Ginkgolide Injection Combined with Citicoline Sodium Tablets on Cerebral Hemodynamics,Oxidative Stress and Serum MCP-1 and Lp-PLA2 in Patients with Cerebral Infarction Convalescence
Objective:To study the effects of ginkgolide injection combined with citicoline sodium tablets on cerebral hemodynamics,oxidative stress and serum monocyte chemoattractant protein-1(MCP-1)and lipoprotein-associated phospholipase A2(Lp-PLA2)in patients with cerebral infarction convalescence.Methods:According to the random number table method,146 patients with cerebral infarction convalescence in The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were divided into control group(n=73,treated with conventional therapy and citicoline sodium tablets)and study group(n=73,combined with ginkgolide injection on the basis of the control group).The clinical efficacy,Barthel index(BI)score,National Institutes of Health Stroke Scale(NIHSS)score,cerebral hemodynamics indicators,serum oxidative stress indicators,MCP-1,Lp-PLA2 and medication safety were compared between two groups.Results:Compared with the 82.19％clinical total effective rate in control group,the 97.26％in study group was higher(P＜0.05).After treatment,BI score,mean blood flow velocity(Vm),serum superoxide dismutase(SOD)and catalase(CAT)in study group were higher than those in control group,and NIHSS score,pulsatility index(PI),resistance index(RI),serum reactive oxygen species(ROS),serum MCP-1 and Lp-PLA2 were lower than those in control group(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Ginkolide injection combined with citicoline sodium tablets can reduce neurological function damage in patients with cerebral infarction convalescence,improve cerebral hemodynamics,reduce oxidative stress,regulate serum MCP-1 and Lp-PLA2 levels,and have good drug safety.
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