Study on the Relationship between Serum Total Bilirubin,Uric Acid,Triglyceride-Glucose Index and Diabetic Retinopathy in Type 2 Diabetes Mellitus with Standard Blood Glucose Control
Objective:To investigate the relationship between serum total bilirubin(TBIL),uric acid(UA),triglyceride-glucose in-dex(TyGI)and diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(T2DM)with standard blood glucose control.Methods:317 T2DM patients with standard blood glucose control from Xuanwu Hospital of Capital Medical University from January 2021 to October 2023 were selected,and patients were divided into proliferative DR(PDR)group(93 cases),non-PDR group(105 cases)and normal fundus group(119 cases)according to the occurrence of DR and the severity of the disease.Serum TBIL and UA levels were measured and TyGI was calculated.The factors of DR in T2DM patients with standard blood glucose control were analyzed by multivari-ate Logistic regression,the predictive value of serum TBIL,UA and TyGI for DR in T2DM patients with standard blood glucose control were analyzed by receiver operating characteristic(ROC)curve.Results:TBIL in PDR group was lower than that in non-PDR group and normal fundus group,UA and TyGI were higher than those in non-PDR group and normal fundus group(P＜0.05).TBIL in non-PDR group was lower than that in normal fundus group,and UA and TyGI were higher than those in normal fundus group(P＜0.05).Multivari-ate Logistic regression analysis showed that prolonged course of T2DM,elevated triglyceride,elevated UA,and elevated TyGI were in-dependent risk factors for DR in T2DM patients with standard blood glucose control,and elevated TBIL was an independent protective factor(P＜0.05).The area under the curve of serum TBIL,UA and TyGI combined to predict DR in T2DM patients with standard blood glucose control was 0.832,which was greater than 0.709,0.695 and 0.746 predicted by serum TBIL,UA and TyGI alone.Conclusion:The decrease of serum TBIL and the increase of UA and TyGI are independent risk factors for DR in T2DM patients with standard blood glucose control,the combination of serum TBIL,UA and TyGI has a higher predictive value for DR in T2DM patients with standard blood glucose control.
Type 2 diabetes mellitusStandard blood glucose controlDiabetic retinopathyTotal bilirubinUric acidTriglyc-eride-glucose index
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