Analysis of Changes and Predictive Value of TM,TAT,PIC and D-D Levels in Patients with Disseminated Intravascular Coagulation
Objective:To explore the changes and predictive value of thrombomodulin(TM),thrombin-antithrombin complex(TAT),plasmin-antiplasmin complex(PIC)and D-dimer(D-D)in patients with disseminated intravascular coagulation(DIC).Methods:The clinical data of 80 patients with suspected DIC admitted to Shanghai Seventh People's Hospital from June 2020 to June 2023 were retrospectively analyzed.According to the comprehensive diagnosis results,thepatients were divided into DIC group(48 cases)and non-DIC group(32 cases).The differences in serum TM,TAT,PIC and D-D levels and International Society of Thrombosis and Hemostasis(ISTH)DIC scoring systemscore were compared between the two groupsat admission.Receiver operating characteristic(ROC)curve was used to evaluate the efficiency of serum TM,TAT,PIC and D-D levels at admission in the early diagnosis of DIC.Pearson correlation coefficient was applied to evaluate the relationship between serum TM,TAT,PIC and D-D levelsat admission and ISTH scorein patients with DIC.The 3-month survival status of patients in DIC group was recorded and the patients were classified into survival group and death group,and the differences in levels of TM,TAT,PIC and D-D at admission were compared.Results:The levels of TM,TAT,PIC and D-D and ISTH score in DIC group were significantly higher than those in non-DIC group(all P＜0.05).The com-bined diagnosis with TM,TAT,PIC and D-D had the highest efficiency,with AUC of 0.926,specificity of 87.50％and sensitivity of 87.50％,and the levels of the four indicators were positively correlated with ISTH score(all P＜0.05).The levels of TM,TAT,PIC and D-D were higherin death group than those in survival group(all P＜0.05).Conclusion:The combination of TM,TAT,PIC and D-D can improve the diagnostic efficiency of early DIC,predict the prognosis of DIC,and provide the best timing for clinical treatment.
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