Comparative Study of the Effects of Dexmedetomidine and Propofol on Hemodynamics,Stress Response and Immune Function in Children Undergoing Liver Mass Resection
Objective:To compare the effects of dexmedetomidine and propofol on hemodynamics,stress response and immune function in children undergoing liver mass resection.Methods:The random number table method was used,90 children who underwent elective liver mass resection in our hospital from May 2021 to April 2023 were divided into dexmedetomidine group(dexmedetomidine anesthesia)and propofol group(propofol anesthesia),45 cases in each group.The changes of hemodynamics[heart rate(HR),mean arte-rial pressure(MAP)],stress response[cortisol(Cor),adrenocorticotropic hormone(ACTH)]and T lymphocyte subsets[CD4+,CD8+,CD4+/CD8+]were compared between two groups,and the incidence of adverse reactions during anesthesia was observed.Results:MAP in dexmedetomidine group was lower than that in propofol group at 10 min after anesthesia induction(T1)to the end of operation(T4),and HR was higher than that in propofol group(P＜0.05).Cor and ACTH in dexmedetomidine group were lower than those in propofol group at T4 and 1 day after operation(T5)(P＜0.05).CD8+in dexmedetomidine group was lower than that in propofol group at T4 and T5,while CD4+and CD4+/CD8+were higher than those in propofol group(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Compare with propofol anesthesia,dexmedetomidine can better stabilize hemody-namics,reduce stress response,and reduce immunosuppression in children undergoing liver mass resection.
DexmedetomidinePropofolLiver massLiver operationHemodynamicsStress responseImmune function
NETL
NSTL
万方数据
