The Influence Factors of Skin Pruritus in Maintenance Hemodialysis Patients and Its Correlation with Serum Inflammatory Factors and β2-MG
Objective:To explore the influencing factors of concurrent skin pruritus in maintenance hemodialysis patients and its correlation with serum inflammatory factors in β2-MG.Methods:100 maintenance hemodialysis patients from our hospital from January 2019 to December 2023,compared with general data and laboratory indicators of patients with and without pruritus,and statistically sig-nificant indicators for Logistic-analysis.The scores of pruritus patients were evaluated according to the 5D-IS scale,and the pruritus pa-tients were divided into mild,moderate and severe groups according to the scores,and the serum inflammatory factors and β2-MG levels of the three groups were compared.The therapeutic effect of pregabalin was analyzed,and the serum levels of β2-MG,CRP,TNF-α and IL-6 in the effective and ineffective groups were compared before and after treatment.Results:In the itching group,age,blood creatinine level,dialysis age,calcium and phosphorus product,blood phosphorus level,parathyroid hormone level,dry skin disease,serum β2-MG,CRP,TNF-α,and IL-6 levels were significantly higher than in the no itching group,while SF level and Kt/V 1.2 proportion were signifi-cantly lower than in the no itching group(P＜0.05).Binary Logistic regression analysis found that The risk factors of maintenance hemodialysis complicated with itching were age ≥60 years,dialysis duration ≥1 year,calcium-phosphorus product ≥65(mg2/dl2),Kt/V＜1.2,parathyroid hormone level ≥300 pg/mL,dry skin disease,serum β2-MG≥4.06 mg/L,serum CRP ≥10 mg/L,and serum TNF-α ≥ 1.54 ng/mL,serum IL-6 ≥ 0.46 ng/L(P＜0.05).Among 45 patients with maintenance hemodialysis complicated with pruritus,28 cases were mild,10 cases were moderate,and 7 cases were severe.Serum levels of β2-MG,CRP,TNF-α and IL-6 in severe group were higher than those in mild and moderate groups,and the above indexes in moderate group were higher than those in mild group(all P＜0.05).Among 45 patients with pruritus caused by maintenance hemodialysis,15 cases had complete remission,10 cases had obvious effect,10 cases were effective,and 10 cases were ineffective.After treatment,the levels of serum β2-MG,CRP,TNF-α and IL-6 in the effective group were lower than those before treatment(P＜0.05).There was no significance in the ineffective group before and after treatment(P＞0.05).After treatment,the above indexes in effective group were lower than those in ineffective group(P＜0.05).Conclusion:The risk factors for pruritosis in maintenance hemodialysis patients included age ≥ 60 years,dialysis duration ≥1 year,calcium-phosphorus prod-uct ≥65(mg2/dl2),Kt/V＜1.2,parathyroid hormone level ≥300 pg/mL,dry skin disease,serum β2-MG ≥4.06 mg/L,serum CRP ≥10 mg/L Serum TNF-α ≥1.54 ng/mL,serum IL-6 ≥ 0.46 ng/L,serum CRP,TNF-α,IL-6 and β2-MG were correlated with the severity and prognosis of skin itching complicated by maintenance hemodialysis patients.
Maintenance hemodialysisSkin itchingThe degree of severityRisk factorsInflammatory factorsβ2-MG
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万方数据
