Expression of CMTM4 and PD-L1 Proteins in Pancreatic Cancer and Their Relationship with Clinicopathological Features
Objective:To explore the expression status of CMTM 4 and PD-L1 protein in pancreatic cancer tissues and analyzed the relationship between the clinician and clinicopathological features.Methods:From January 2016 to 2020.1,our Hospital of Inner Mongolia Medical University collected 40 cases as the experimental group,and selected adjacent tissues as the control group,to detect the expression of CMTM 4 and PD-L1 protein by immunohistochemistry Envision,the expression of CMTM 4 and PD-L1 protein in can-cer tissues and adjacent tissues,and the relationship between the two and clinical pathological features.Results:CMTM 4 is mainly dis-tributed in tumor cell membrane and cytoplasm,both brown or brown particles;PD-L1 is mainly distributed in tumor stromal immune cells,cell membrane and cytoplasm,brown or light yellow.The levels of CMTM 4 and PD-L1 in pancreatic cancer were higher than those in adjacent cancer(P＜0.05).Compared with adjacent tissues,pancreatic cancer tissues had high expression of CMTM 4 protein and PD-L1 protein,and low expression of CMTM 4 protein and PD-L1 protein was lower than adjacent tissues(P＜0.05).The incidence of nerve invasion with high PD-L1 expression and lymph node metastasis was higher than that of CMTM 4 and PD-L1 expression(P＜0.05);however,gender,age,tumor site,tumor diameter,tissue differentiation,TNM stage,high CMTM 4 expression and high PD-L1 protein expression and low CMTM 4 protein and low PD-L1 expression(P＞0.05).CMTM 4 protein and PD-L1 protein expression were not cor-related with the degree of tissue differentiation or TNM stage of pancreatic cancer(P＞0.05).Conclusion:CMTM4 and PD-L1 proteins are highly expressed in pancreatic cancer tissues,which are related to nerve invasion and lymph node metastasis.
CMTM4 proteinPD-L1 proteinPancreatic cancer tissueNerve invasionLymph node metastasis
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