Effects of Saphenous Nerve Pulsed Radiofrequency Combined with Intra-Articular Injection of Sodium Hyaluronate on Oxidative Stress and Inflammatory Pain Mediators in Patients with Knee Osteoarthritis Who are Ineffective in Conservative Treatment
Objective:To observe the effects of saphenous nerve pulsed radiofrequency combine with intra-articular injection of sodium hyaluronate on oxidative stress and inflammatory pain mediators in patients with knee osteoarthritis(KOA)who are ineffective in conservative treatment.Methods:127 KOA patients who were ineffective in conservative treatment in our hospital from July 2021 to De-cember 2022 were selected,according to the random number table method,the patients were divided into control group(n=63,received intra-articular injection of sodium hyaluronate)and combination group(n=64,received saphenous nerve pulsed radiofrequency combine with intra-articular injection of sodium hyaluronate).The knee pain visual analogue(VAS)score,Lysholm knee function score(Lysholm score),inflammatory mediators[interleukin-1β(IL-1 β),interleukin-1(IL-1),tumor necrosis factor-α(TNF-α),pain mediators[substance P(SP),5-hydroxytryptamine(5-HT),prostaglandin E2(PGE2)],oxidative stress indexes[superoxide dismutase(SOD),glutathione peroxi-dase(GSH-Px),malondialdehyde(MDA)]and adverse reactions were compared between two groups.Results:The VAS score in combi-nation group was lower than that in control group post-treatment,and the Lysholm score was higher than that in control group(P＜0.05).MDA in combination group was lower than that in control group post-treatment,GSH-Px and SOD were higher than those in control group(P＜0.05).IL-1β,IL-1 and TNF-α in combination group were lower than those in control group post-treatment(P＜0.05).SP,5-HT and PGE2 in combination group were lower than control group post-treatment(P＜0.05).There was no difference in the incidence of ad-verse reactions between two groups(P＞0.05).Conclusion:Saphenous nerve pulsed radiofrequency combined with intra-articular injection of sodium hyaluronate can relieve pain,reduce the levels of oxidative stress and inflammatory pain mediators,and promote the recovery of knee joint function in KOA patients with ineffective conservative treatment,and has good safety.
NETL
NSTL
万方数据
