The Effect of Brain Biomimetic Electrical Stimulation Combined with Ginaton Injection on Hearing Threshold Gain and Cochlear Function in the Treatment of Sudden Deafness
Objective:To explore the effect of brain biomimetic electrical stimulation combined with Ginkgo biloba injection on hearing threshold gain and cochlear function in the treatment of sudden deafness.Methods:A total of 140 cases of patients with sudden deafness admitted to our hospital from October 2020 to October 2023 were selected and divided into observation group and matched group,with 70 cases each.The matched group patients received treatment with Ginaton injection,while the observation group received treatment with brain biomimetic electrical stimulation combined with Ginaton injection.Compare the clinical efficacy,cochlear function and hearing threshold gain before and Post-treatment between two groups of patients,as well as changes in anti endothelial cell antibody(AECA),soluble vascular intercellular adhesion factor-1(sVCAM-1),endothelin(ET)related blood biomarker levels,and hemorheologi-cal indicators.Results:The total effective rate of the observation group was higher than that of the matched group(P＜0.05);Pretherapy,there was no difference in the pure tone air conduction hearing threshold and decibels of hearing loss between the two groups of patients(P＞0.05).Post-treatment,the pure tone air conduction hearing threshold and decibels of hearing loss decreased in both groups,with the observation group being lower than the matched group.At the same time,the gain value of the observation group's hearing threshold was higher than that of the matched group(P＜0.05);Pretherapy,there was no difference in the levels of AECA,sVCAM-1,and ET between the two groups of patients(P＞0.05).Post-treatment,both groups decreased,with the observation group being lower than the matched group(P＜0.05);There was no difference in plasma viscosity and whole blood viscosity between the two groups(P＞0.05),which decreased Post-treatment,and the observation group was lower than the matched group(P＜0.05).Conclusion:Brain biomimetic electrical stimula-tion combined with Ginaton injection can enhance the therapeutic effect of sudden deafness,improve cochlear function,increase hearing threshold,and reduce the expression levels of blood markers AECA,sVCAM-1,and ET related to sudden deafness,reducing blood hy-percoagulability.It is worth promoting in clinical practice.
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