Correlation Analysis of Serum Leptin,25-(OH)D3 and Glucose and Lipid Metabolism,Growth and Development and Renin-Angiotensin-Aldosterone System in Children with Simple Obesity
Objective:To study the correlation between serum leptin(Leptin),25-hydroxyvitamin D3[25-(OH)D3]and glucose and lipid metabolism,growth and development and renin-angiotensin-aldosterone system(RAS)in children with simple obesity.Methods:132 children with simple obesity admitted to Shanxi Children's Hospital from September 2021 to September 2023 were selected as obser-vation group,and 100 healthy children who underwent physical examination during the same period were selected as control group.Serum Leptin,25-(OH)D3,glucose and lipid metabolism indexes[fasting blood glucose(FBG),triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)]and RAS system indexes[renin(PRA),angiotensin-Ⅱ(Ang-Ⅱ),aldosterone(ALD)]were detected,and growth and development indexes[body mass index(BMI),waist circumference(WC),waist-hip ratio(WHR)]were measured.The correlation between serum Leptin,25-(OH)D3 and glucose and lipid metabolism,growth and develop-ment and RAS indexes in children with simple obesity were analyzed by Pearson test.Results:Serum Leptin in observation group was higher than that in control group,and 25-(OH)D3 was lower than that in control group(P＜0.05).FBG,TG,TC and LDL-C in observation group were higher than those in control group,while HDL-C was lower than that in control group(P＜0.05).BMI,WC and WHR in ob-servation group were higher than those in control group(P＜0.05).The PRA,Ang-Ⅱ and ALD in observation group were higher than those in control group(P＜0.05).Pearson test showed that,serum Leptin was positively correlated with FBG,TG,TC,LDL-C,BMI,WC,WHR,PRA,Ang-Ⅱ and ALD,and negatively correlated with HDL-C,25-(OH)D3 was negatively correlated with FBG,TG,TC,LDL-C,BMI,WC,WHR,PRA,Ang-Ⅱ and ALD,and positively correlated with HDL-C(all P＜0.05).Conclusion:In children with simple obesity,serum Leptin is highly express and 25-(OH)D3 is lowly express,which is closely relate to glucose and lipid metabolism,growth and development,and RAS system.Serum Leptin and 25-(OH)D3 may be involve in the pathogenesis of children with simple obesity by affecting glucose and lipid metabolism,growth and development and RAS system.
Simple obesityChildrenLeptin25-(OH)D3Glucose and lipid metabolismGrowth and developmentRenin-angiotensin-aldosterone systemCorrelation
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