摘要
目的:研究单纯性肥胖儿童血清瘦素(Leptin)、25羟基维生素D3[25-(OH)D3]与糖脂代谢、生长发育和肾素-血管紧张素-醛固酮系统(RAS)的相关性.方法:选取2021年9月～2023年9月山西省儿童医院收治的132例单纯性肥胖儿童纳入观察组,另选同期健康体检的健康儿童100例纳入对照组.检测血清Leptin、25-(OH)D3、糖脂代谢指标[空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)]及RAS系统指标[肾素(PRA)、血管紧张素-Ⅱ(Ang-Ⅱ)、醛固酮(ALD)],并测量生长发育指标[体质指数(BMI)、腰围(WC)、腰臀比(WHR)].采用Pearson检验对单纯性肥胖儿童血清Leptin、25-(OH)D3与糖脂代谢、生长发育和RAS指标的相关性进行分析.结果:观察组血清Leptin高于对照组,25-(OH)D3低于对照组(P＜0.05).观察组FBG、TG、TC、LDL-C高于对照组,而HDL-C低于对照组(P＜0.05).观察组BMI、WC、WHR高于对照组(P＜0.05)o观察组 PRA、Ang-Ⅱ、ALD 高于对照组(P＜0.05).经 Pearson 检验分析,血清 Leptin 与 FBG、TG、TC、LDL-C、BMI、WC、WHR、PRA、Ang-Ⅱ、ALD 呈正相关性,与 HDL-C 呈负相关性,25-(OH)D3 与 FBG、TG、TC、LDL-C、BMI、WC、WHR、PRA、Ang-Ⅱ、ALD呈负相关性,与HDL-C呈正相关性(均P＜0.05).结论:单纯性肥胖儿童中,血清Leptin呈高表达,25-(OH)D3为低表达,并且与患儿的糖脂代谢、生长发育及RAS系统密切相关.血清Leptin、25-(OH)D3可能通过对机体糖脂代谢、生长发育及RAS系统的影响而参与到儿童单纯性肥胖的发病过程.
Abstract
Objective:To study the correlation between serum leptin(Leptin),25-hydroxyvitamin D3[25-(OH)D3]and glucose and lipid metabolism,growth and development and renin-angiotensin-aldosterone system(RAS)in children with simple obesity.Methods:132 children with simple obesity admitted to Shanxi Children's Hospital from September 2021 to September 2023 were selected as obser-vation group,and 100 healthy children who underwent physical examination during the same period were selected as control group.Serum Leptin,25-(OH)D3,glucose and lipid metabolism indexes[fasting blood glucose(FBG),triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)]and RAS system indexes[renin(PRA),angiotensin-Ⅱ(Ang-Ⅱ),aldosterone(ALD)]were detected,and growth and development indexes[body mass index(BMI),waist circumference(WC),waist-hip ratio(WHR)]were measured.The correlation between serum Leptin,25-(OH)D3 and glucose and lipid metabolism,growth and develop-ment and RAS indexes in children with simple obesity were analyzed by Pearson test.Results:Serum Leptin in observation group was higher than that in control group,and 25-(OH)D3 was lower than that in control group(P＜0.05).FBG,TG,TC and LDL-C in observation group were higher than those in control group,while HDL-C was lower than that in control group(P＜0.05).BMI,WC and WHR in ob-servation group were higher than those in control group(P＜0.05).The PRA,Ang-Ⅱ and ALD in observation group were higher than those in control group(P＜0.05).Pearson test showed that,serum Leptin was positively correlated with FBG,TG,TC,LDL-C,BMI,WC,WHR,PRA,Ang-Ⅱ and ALD,and negatively correlated with HDL-C,25-(OH)D3 was negatively correlated with FBG,TG,TC,LDL-C,BMI,WC,WHR,PRA,Ang-Ⅱ and ALD,and positively correlated with HDL-C(all P＜0.05).Conclusion:In children with simple obesity,serum Leptin is highly express and 25-(OH)D3 is lowly express,which is closely relate to glucose and lipid metabolism,growth and development,and RAS system.Serum Leptin and 25-(OH)D3 may be involve in the pathogenesis of children with simple obesity by affecting glucose and lipid metabolism,growth and development and RAS system.
基金项目
山西省科技厅软科学研究项目(2018041035-2)
NETL
NSTL
万方数据