Changes of Serum BNP,PCT and SIGIRR in Patients with Emergency Abdominal Infection-related Sepsis and Relationship with Prognosis
Objective:To investigate the changes of serum brain natriuretic peptide(BNP),procalcitonin(PCT)and recombinant single Ig ILl related receptor(SIGIRR)in patients with emergency abdominal infection-related sepsis and their relationship with progno-sis.Methods:318 patients with emergency abdominal infection who were received by our hospital from January 2020 to October 2023 were divided into simple infection group(n=233)and sepsis group(n=85)according to whether sepsis occurred.The baseline data and serum BNP,PCT and SIGIRR levels were compared between groups.Pearson correlation analysis was used to explore the correlation be-tween serum indicators and clinical data.The patients in sepsis group were classified into survival group(n=56)and death group(n=29)by means of survival status within 28 days,and the baseline data,serum BNP,PCT and SIGIRR were compared.Binary logistics equa-tion was used to analyze the related influencing factors of prognosis of patients with sepsis.ROC curve was adopted to analyze the diag-nostic value of serum BNP,PCT and SIGIRR levels on prognosis of sepsis group.Results:There were significant differences in pathogen types,WBC,CRP,ALB,APACHE Ⅱ score and SOFA score between simple infection group and sepsis group(P＜0.05).The levels of serum BNP,PCT and SIGIRR in simple infection group were significantly lower than those in sepsis group(P＜0.05).Pearson correlation analysis showed that the levels of BNP,PCT and SIGIRR in sepsis group were positively correlated with WBC,CRP,APACHE Ⅱ score and SOFA score(P＜0.05),and were negatively correlated with ALB(P＜0.05).Among patients with sepsis,the levels of serum BNP,PCT and SIGIRR were significantly higher in death group than those in survival group(P＜0.05).Binary logistics regression analysis showed that serum BNP,PCT and SIGIRR levels were associated with poor prognosis in patients with sepsis(P＜0.05).ROC curve revealed that the AUCs of serum BNP,PCT,SIGIRR alone and in combination in predicting the poor prognosis in patients with sepsis were 0.876,0.826,0.779 and 0.976,the sensitivities were 86.21％,82.76％,75.86％and 96.55％,and the specificities were 75％,75％,71.43％and 69.64％respectively,and the combined diagnostic value was higher.Conclusion:BNP,PCT and SIGIRR have a certain correlation with patients with abdominal infection-related sepsis,and can be used as reference indicators for clinical diagnosis,treatment and prognosis evaluation.
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