Study on the Relationship between Serum LncRNA-PVT1,miR-497-5p Expression and Lung Function and Prognosis in Patients with Chronic Obstructive Pulmonary Disease with Lung Cancer
Objective:To study the relationship between serum long chain non coding RNA-human plasmacytoma transformation and migration gene 1(LncRNA-PVTl),microribonucleic acid-497-5p(miR-497-5p)expression and lung function and prognosis in patients with chronic obstructive pulmonary disease(COPD)with lung cancer.Methods:116 patients with COPD combined with lung cancer un-derwent concurrent surgical treatment admitted to Linyi Cancer Hospital from March 2018 to March 2020 were selected as the observa-tion group,while 50 patients with simple COPD during the same period were included in the control group.The relative expression levels of serum LncRNA-PVT1 and miR-497-5p and lung function indexes[forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),FEV1/FVC,percentage of forced expiratory volume in the first second to predicted value(FEV1％pred)]were compared between two groups.The correlation between serum LncRNA-PVTl,miR-497-5p expression and lung function indexes in patients with COPD with lung cancer were analyzed by Pearson test.Patients with COPD with lung cancer were followed up for 3 years after opera-tion,the prognostic factors of patients with COPD with lung cancer were analyzed by multivariate Cox regression model.3 years overall survival rate of patients with low expression and high expression of LncRNA-PVT1 and miR-497-5p were analyzed by drawn Ka-plan-Meier survival curve.Results:Compared with control group,the expression level of serum LncRNA-PVT1 in observation group was significantly increased(P＜0.05),and the expression level of miR-497-5p was significantly decreased(P＜0.05).Compared with con-trol group,FEV1,FEV1％pred and FEV1/FVC in observation group were significantly lower(P＜0.05).Pearson test results showed that,serum LncRNA-PVT1 was negatively correlated with FEV1,FEV1％pred and FEV1/FVC in patients with COPD with lung cancer(P＜0.05);serum miR-497-5p was positively correlated with FEV1,FEV1％pred and FEV1/FVC(P＜0.05).The Kplan-Meier survival curve showed that,the 3 years overall survival rate in LncRNA-PVT1 high expression group was 29.23％,which was significantly lower than 47.73％in LncRNA-PVT1 low expression group(P＜0.05).3 years overall survival rate in miR-497-5p high expression group was 46.77％,which was significantly higher than 23.40％in miR-497-5p low expression group(P＜0.05).Multivariate Cox regression analysis showed that,lymph node metastasis,TNM stage Ⅲa,poor differentiation of tumor tissue,high expression of LncRNA-PVT1 and low expression of miR-497-5p were risk factors for prognosis of patients with COPD with lung cancer(P＜0.05).Conclusion:LncRNA-PVT1 is highly expresse and miR-497-5p is lowly expresse in the serum of patients with COPD with lung cancer,the expression level is relate to lung function indexes,and the higher the expression level of LncRNA-PVT1 and the lower the expression level of miR-497-5p,the lower the 3 years overall survival rate.
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