Analysis of HPV Infection,Genotype Distribution,and Vaginal Microbiota Changes in Female Patients with Cervical Lesions
Objective:To analyze the Human Papillomavirus(HPV)infection status,genotype distribution,and vaginal microbiota changes in women with cervical lesions.Methods:A total of 92 women with cervical lesions were enrolled in the study group from June 2022 to June 2023.Additionally,92 healthy women without cervical lesions during the same period were included in the control group.The study compared the HPV infection status,genotype distribution,vaginal microbiota assessment,and functional indices between the study and control groups.Results:The HPV infection rate in the study group was 73.91％,significantly higher than 13.04％in the control group.The rates of single HPV infection and mixed infection in the study group were 54.35％and 19.56％,respectively,significantly higher than 11.96％and 1.09％in the control group(P＜0.05).The most prevalent HPV genotypes in the study group were HPV 16 and HPV 18,with detection rates of 45.65％and 35.87％,respectively,both significantly higher than in the control group(P＜0.05).Addition-ally,the study group exhibited higher detection rates of Chlamydia,Mycoplasma,Trichomonas,and Bacterial Vaginosis(P＜0.05).The proportion of Lactobacillus as the dominant bacteria and vaginal pH ≤4.5 was lower in the study group(P＜0.05).The positivity rates of leukocyte esterase,sialidase,and β-glucuronidase were elevated in the study group(P＜0.05).Conclusion:Women with cervical lesions have a significantly higher rate of high-risk HPV infection and detection of genotypes like HPV 16 and HPV 18 compared to the normal population.There are also significant changes in the vaginal microbiota of these patients,with increased detection rates of pathogens and elevated levels of leukocyte esterase,sialidase,and β-glucuronidase.
NETL
NSTL
万方数据
