复发性流产患者血清IL-33/ST2轴水平的表达及其预测价值分析
Expression of Serum IL-33/ST2 Axis Levels in Patients with Recurrent Spontaneous Abortion and Analysis of Their Predictive Value
董丹彤 1周玲 1刘娟娟 1洪苏倩 1李雪1
作者信息
- 1. 苏州大学附属第二医院生殖医学中心 江苏苏州 215004
- 折叠
摘要
目的:探讨复发性流产(RSA)患者血清白细胞介素-33(IL-33)/生长刺激表达基因2(ST2)轴水平的表达及其预测价值.方法:选取2021年1月～2023年1月苏州大学附属第二医院就诊的80例RSA患者为RSA组,另选取同期80名无异常妊娠史的孕妇为对照组.通过酶联免疫吸附法检测血清IL-33、可溶性ST2(sST2)水平.采用Pearson相关性分析RSA患者血清IL-33与sST2水平的相关性,采用多因素Logistic回归分析影响RSA的因素,采用受试者工作特征(ROC)曲线分析血清IL-33、sST2水平对RSA的预测价值.结果:与对照组比较,RSA组血清IL-33、sST2水平升高(P＜0.05).Pearson相关性分析显示,RSA患者血清IL-33与sST2水平呈正相关(r=0.746,P＜0.001).多因素Logistic回归分析显示,生殖道感染、血清IL-33、sST2水平升高为RSA发生的独立危险因素(P＜0.05)oROC曲线分析显示,血清IL-33、sST2水平联合预测RSA的AUC为0.888,大于血清IL-33、sST2水平单独预测的0.794、0.840.结论:RSA患者血清IL-33、sST2水平升高是RSA发生的独立危险因素,IL-33/ST2轴水平异常表达参与RAS发生过程.血清IL-33、sST2水平联合检测对RSA具有较高的预测价值.
Abstract
Objective:To investigate the expression of serum interleukin-33(IL-33)/suppression of tumorigenicity 2(ST2)axis levels and its predictive value in patients with recurrent spontaneous abortion(RSA).Methods:80 patients with RSA treated in The Sec-ond Affiliated Hospital of Soochow University from January 2021 to January 2023 were selected as the RSA group,and another 80 preg-nant women with no history of abnormal pregnancy who underwent abortion during the same period were selected as the control group.Serum IL-33 and soluble ST2(sST2)levels were measured by enzyme-linked immunosorbent assay.Pearson correlation was used to ana-lyze the correlation between serum IL-33 and sST2 levels in patients with RSA,multivariate Logistic regression was used to analyze the factors affecting RSA,and the predictive value of serum IL-33 and sST2 levels for RSA was analyzed by receiver operating characteristic(ROC)curve.Results:Compared with the control group,the serum IL-33 and sST2 levels in the RSA group increased(P＜0.05).Pearson correlation analysis showed a positive correlation between serum IL-33 and sST2 levels in patients with RSA(r=0.746,P＜0.001).Multi-variate Logistic regression analysis showed that reproductive tract infection,elevated serum IL-33 and sST2 levels were independent risk factors for RSA(P＜0.05).ROC curve analysis showed that the AUC of RSA predicted by the combination of serum IL-33 and sST2 levels was 0.888,which was higher than the 0.794 and 0.840 predicted by serum IL-33 and sST2 levels alone.Conclusion:Elevated serum IL-33 and sST2 levels in RSA patients are independent risk factors for the occurrence of RSA,and abnormal expression of IL-33/ST2 axis levels is involved in the process of RAS.The combined detection of serum IL-33 and sST2 levels has high predictive value for RSA.
关键词
复发性流产/白细胞介素-33/生长刺激表达基因2/预测价值Key words
Recurrent spontaneous abortion/Interleukin-33/Suppression of tumorigenicity 2/Predictive value引用本文复制引用
基金项目
苏大附二院科研预研基金项目(SDFEYJLC2102)
江苏省妇幼健康科研项目(F201757)
出版年
2024
NETL
NSTL
万方数据