Study on the Relationship between Serum NRG1,FGL2,FGF9 and Epilepsy after Acute Ischemic Stroke and its Predictive Value
Objective:To investigate the relationship between serum neuromodulin-1(NRG1),fibrinogen-like protein 2(FGL2),fibroblast growth factor 9(FGF9)and epilepsy after acute ischemic stroke(AIS)and its predictive value.Methods:450 AIS patients admitted to Longquan Hospital of Sichuan University West China Hospital from January 2021 to March 2022 were selected,and the patients were divided into epilepsy group(n=41)and non-epilepsy group(n=409)according to whether epilepsy occurred after 1 year of follow-up.The levels of serum NRG1,FGL2 and FGF9 were detected by enzyme-linked immunosorbent assay(ELISA).The factors affecting epilepsy after AIS were analyzed by multivariate Logistic regression analysis,and the predictive value of serum NRG1,FGL2 and FGF9 levels for epilepsy after AIS were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with non-epileptic group,the serum levels of NRG 1 and FGL2 in epileptic group increased,and the FGF9 level decreased,the difference was statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that anterior circulation infarction,the increased infarct area,hemorrhagic transformation,the increase of National Institute of Health stroke scale(NIHSS)score,NRG1 and FGL2 were indepen-dent risk factors for epilepsy after AIS,and the increase of FGF9 was an independent protective factor(P＜0.05).ROC curve analysis showed that the area under the curve of serum NRG1,FGL2 and FGF9 levels combined to predict epilepsy after AIS was 0.921,which was greater than 0.789,0.779 and 0.795 predicted by serum NRG1,FGL2 and FGF9 levels alone.Conclusion:The increased serum NRG1 and FGL2 levels and decreased FGF9 levels are closely associated with epilepsy after AIS,and the combined detection of serum NRG1,FGL2,and FGF9 levels is of high value in predicting epilepsy after AIS.
Acute ischemic strokeEpilepsyNRG1FGL2FGF9Predictive value
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