首页|血清GGT、CysC、ApoB/ApoA1比值与急性ST段抬高型心肌梗死合并2型糖尿病患者预后的关系

血清GGT、CysC、ApoB/ApoA1比值与急性ST段抬高型心肌梗死合并2型糖尿病患者预后的关系

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目的:探讨血清γ-谷氨酰转移酶(GGT)、胱抑素C(CysC)、载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)比值与急性ST段抬高型心肌梗死(ASTEMI)合并2型糖尿病(T2DM)患者预后的关系。方法:回顾性收集175例在广东省中医院行经皮冠状动脉介入治疗(PCI)的ASTEMI合并T2DM患者的临床资料，根据PCI术后1个月的预后分为不良预后组(63例)和良好预后组(112例)，检测血清GGT、CysC水平和计算ApoB/ApoA1比值。采用多因素Logistic回归分析ASTEMI合并T2DM患者PCI术后不良预后的因素，受试者工作特征曲线(ROC)分析血清GGT、CysC、ApoB/ApoA1比值对ASTEMI合并T2DM患者PCI术后不良预后的预测价值。结果:术后随访1个月，175例ASTEMI合并T2DM患者PCI术后不良预后发生率为36。00％(63/175)。与良好预后组比较，不良预后组血清GGT、CysC、ApoB/ApoA1比值升高(P＜0。05)o Killip分级≥Ⅱ级和血清GGT、CysC、ApoB/ApoA1比值升高为ASTEMI合并T2DM患者PCI术后不良预后的独立危险因素(P＜0。05)。血清GGT、CysC、ApoB/ApoA1比值联合预测ASTEMI合并T2DM患者PCI术后不良预后的曲线下面积(AUC)为0。924，大于血清GGT、CysC、ApoB/ApoA1比值单独预测的0。776、0。778、0。785。结论:血清GGT、CysC、ApoB/ApoA1比值升高与ASTEMI合并T2DM患者PCI术后不良预后有关，血清GGT、CysC、ApoB/ApoA1比值联合检测对ASTEMI合并T2DM患者PCI术后不良预后具有较高的预测价值。
Relationship between Serum GGT,CysC,ApoB/ApoA1 Ratio and Prognosis of Patients with Acute ST Elevation Myocardial Infarction Complicated with Type 2 Diabetes Mellitus
Objective:To investigate the relationship between serum γ-glutamyl transferase(GGT),cystatin C(CysC),apolipopro-tein B/apolipoprotein A1(ApoB/ApoA1)ratio and the prognosis of patients with acute ST elevation myocardial infarction(ASTEMI)complicated with type 2 diabetes mellitus(T2DM).Methods:The clinical data of 175 patients with ASTEMI complicated with T2DM who underwent percutaneous coronary intervention(PCI)in Guangdong Provincial Hospital of Traditional Chinese Medicine were retro-spectively collected,patients were divided into poor prognosis group(63 cases)and good prognosis group(112 cases)according to the prognosis at 1 month after PCI,Serum GGT and CysC levels were detected and ApoB/ApoA1 ratio was calculated.The factors affecting the poor prognosis of ASTEMI patients complicated with T2DM after PCI were analyzed by multivariate Logistic regression,the predic-tive value of serum GGT,CysC and ApoB/ApoA1 ratio for the poor prognosis of ASTEMI patients complicated with T2DM after PCI were analyzed by receiver operating characteristic curve(ROC).Results:1 month after follow-up,the incidence of poor prognosis after PCI in 175 ASTEMI patients complicated with T2 DM was 36.00％(63/175).Compared with good prognosis group,the serum GGT,CysC and ApoB/ApoA1 ratio in poor prognosis group increased(P＜0.05).Killip grade≥Ⅱ and elevated serum GGT,CysC,ApoB ApoA1 ratio were independent risk factors for poor prognosis in ASTEMI patients complicated with T2 DM after PCI(P＜0.05).The area under the curve(AUC)of serum GGT,CysC and ApoB/ApoA 1 ratio combined to predict the poor prognosis of ASTEMI patients complicated with T2DM after PCI was 0.924,which was greater than the 0.776,0.778 and 0.785 predicted by serum GGT,CysC and ApoB/ApoA1 ratio alone.Conclusion:Elevated serum GGT,CysC and ApoB/ApoA1 ratio are relate to the poor prognosis of ASTEMI patients compli-cated with T2DM after PCI,and the combined detection of serum GGT,CysC and ApoB/ApoA1 ratio has a high predictive value for the poor prognosis of ASTEMI patients complicated with T2DM after PCI.

Acute ST elevation myocardial infarctionType 2 diabetes mellitus-y-glutamyl transferaseCystatin CApolipoprotein B/apolipoprotein A1 ratioPrognosis

李杰、龙燕、陈秋雄、张磊、尹宪华

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广州中医药大学第二临床医学院 广东广州 510405

广东省中医院心血管内科 广东广州 510120

重庆市永川区中医院急诊科 重庆 402160

急性ST段抬高型心肌梗死 2型糖尿病 γ-谷氨酰转移酶 胱抑素C 载脂蛋白B/载脂蛋白A1比值 预后

广东省基础与应用基础研究基金项目

2022A1515220191

2024

10.13241/j.cnki.pmb.2024.14.015

现代生物医学进展
黑龙江省森工总医院 哈尔滨医科大学附属第四医院

现代生物医学进展

CSTPCD
影响因子：0.755
ISSN：1673-6273
年,卷(期)：2024.24(14)
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