Effects of Ropivacaine Combined with Parecoxib Sodium Serratus Anterior Plane Block on Postoperative Immune Inflammatory Response and Oxidative Stress in Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer
Objective:To investigate the effects of ropivacaine combined with parecoxib sodium serratus plane block(SAPB)on postoperative oxidative stress and immune inflammatory response in patients undergoing thoracoscopic radical resection of lung cancer.Methods:According to the random number table method,110 patients with lung cancer who underwent thoracoscopic radical resection of lung cancer in The Sixth Affiliated Hospital of Nantong University from January 2021 to April 2023 were divided into observation group(ropivacaine combine with parecoxib sodium SAPB,55 cases)and control group(ropivacaine SAPB,55 cases).The postoperative recovery,visual analogue scale(VAS)of pain at rest and cough,immune function,inflammatory response and oxidative stress were com-pared between two groups,and the incidence of adverse reactions during treatment was observed.Results:The postoperative spontaneous breathing recovery time,eye opening time and extubation time in observation group were shorter than those in control group(P＜0.05).The resting VAS and cough VAS in observation group were lower than those in control group 12 h(T2)～48 h(T4)after operation(P＜0.05).The levels of superoxide dismutase(SOD),CD3+,CD4+,CD4+/CD8+in observation group were higher than those in control group at T3 time point.Malondialdehyde(MDA),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and CD8+were lower than those in control group(P＜0.05).The adverse reactions in control group was 7.28％,and that in observation group was 10.92％,with no statistical differ-ence(P＞0.05).Conclusion:Ropivacaine combined with parecoxib sodium SAPB for thoracoscopic radical resection of lung cancer,which can effectively improve the clinical symptoms and immune function,reduce the body's inflammatory and oxidative stress.
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