重组牛碱性成纤维细胞生长因子辅助非剥脱点阵激光对痤疮瘢痕的疗效及皮肤屏障功能影响
Effect of Recombinant Bovine Basic Fibroblast Growth Factor Assisted Non-ablative Fractional Laser on Acne Scar and Skin Barrier Function
尚倩 1党延玲 1朱东宁 1贾煜 1杨丽娟1
作者信息
- 1. 西北妇女儿童医院皮肤科 陕西西安 710061
- 折叠
摘要
目的:评价重组牛碱性成纤维细胞生长因子(rb-bFGF)辅助非剥脱点阵激光治疗痤疮瘢痕的疗效以及对皮肤屏障功能的影响.方法:选入我院2021年5月～2023年5月收治的痤疮瘢痕患者98例,根据治疗方法不同分为对照组和观察组,各49例.两组均予以非剥脱点阵激光治疗,观察组加用rb-bFGF凝胶.评价两组的临床疗效、皮肤屏障功能等,并进行统计比较.结果:观察组恢复期水肿时间、疼痛时间、红斑持续时间、结痂时间和愈合时间显著低于对照组(P＜0.05),ECCA、VSS评分亦明显低于对照组(P＜0.05);观察组愈显率显著高于对照组(79.59％vs.57.14％,P＜0.05);与治疗前相比,两组治疗后皮肤含水量明显升高、经皮水流量显著降低(P＜0.05),而观察组升高/降低幅度明显大于对照组(P＜0.05);观察组治疗后QOL-Acne各项评分均明显高于对照组(P＜0.05).结论:rb-bFGF辅助非剥脱点阵激光治疗痤疮瘢痕疗效肯定,可加快术后症状恢复,改善瘢痕状况及皮肤屏障功能,提高生活质量.
Abstract
Objective:To evaluate the efficacy of recombinant bovine basic fiibroblast growth factor(rb-bFGF)assisted non-abla-tive fractional laser therapy for acne scars and its impact on skin barrier function.Methods:98 patients with acne scars admitted to our hospital from May 2021 to May 2023 were selected and divided into a control group and an observation group based on different treat-ment methods,with 49 patients in each group.Both groups were treated with non-ablative fractional laser,and the observation group was added with rb-bFGF gel.Evaluate and compare the clinical efficacy,skin barrier function,etc.of the two groups.Results:The edema time,pain time,erythema duration,scab formation time and healing time of the observation group were signifiicantly lower than control group(P＜0.05),and the ECCA and VSS scores were also significantly lower than control group(P＜0.05).The markedly effective rate of the observation group was significantly higher than control group(79.59％vs.57.14％,P＜0.05).Compared with before treatment,the skin moisture content of the two groups significantly increased and the transepidermal water loss significantly decreased after treatment(P＜0.05),while the increase/decrease amplitude of the observation group was significantly greater than control group(P＜0.05).After treatment,the QOL Acne scores in the observation group were significantly higher than control group(P＜0.05).Conclusion:The efficacy of rb-bFGF assisted non-ablative fractional laser treatment for acne scars is certain,which can accelerate postoperative symptom recovery,improve scar condition and skin barrier function,and improve quality of life.
关键词
痤疮瘢痕/非剥脱点阵激光/rb-bFGF/凝胶/疗效/皮肤屏障功能Key words
Acne scars/Non-ablative fractional laser/rb-bFGF/Gel/Efficacy/Skin barrier function引用本文复制引用
基金项目
陕西省重点研发计划一般项目(2020SF-031)
出版年
2024
NETL
NSTL
万方数据