Effect of Recombinant Bovine Basic Fibroblast Growth Factor Assisted Non-ablative Fractional Laser on Acne Scar and Skin Barrier Function
Objective:To evaluate the efficacy of recombinant bovine basic fiibroblast growth factor(rb-bFGF)assisted non-abla-tive fractional laser therapy for acne scars and its impact on skin barrier function.Methods:98 patients with acne scars admitted to our hospital from May 2021 to May 2023 were selected and divided into a control group and an observation group based on different treat-ment methods,with 49 patients in each group.Both groups were treated with non-ablative fractional laser,and the observation group was added with rb-bFGF gel.Evaluate and compare the clinical efficacy,skin barrier function,etc.of the two groups.Results:The edema time,pain time,erythema duration,scab formation time and healing time of the observation group were signifiicantly lower than control group(P＜0.05),and the ECCA and VSS scores were also significantly lower than control group(P＜0.05).The markedly effective rate of the observation group was significantly higher than control group(79.59％vs.57.14％,P＜0.05).Compared with before treatment,the skin moisture content of the two groups significantly increased and the transepidermal water loss significantly decreased after treatment(P＜0.05),while the increase/decrease amplitude of the observation group was significantly greater than control group(P＜0.05).After treatment,the QOL Acne scores in the observation group were significantly higher than control group(P＜0.05).Conclusion:The efficacy of rb-bFGF assisted non-ablative fractional laser treatment for acne scars is certain,which can accelerate postoperative symptom recovery,improve scar condition and skin barrier function,and improve quality of life.
Acne scarsNon-ablative fractional laserrb-bFGFGelEfficacySkin barrier function
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