Analysis of the Relationship between Serum Soluble Adhesion Molecule-1,Helper T cell 17 and Systemic Immune Inflammatory Index,Adhesion Degree of Endometriosis Cyst and Postoperative Ovarian Reserve Function
Objective:To analyse the serum levels of soluble adhesion molecule 1(sICAM 1),17 helper T cells(Th17)and system immune inflammation index(SⅡ)and endometriosis cyst degree of adhesion and the relationship between the ovarian reserve function after surgery for.Methods:From January 2020 to October 2023 in our hospital laparoscopic surgical endometriosis cyst removal of 90 cases of ectopic intrauterine membrane cyst patients into the observation group,according to the degree of endometriosis cyst adhesion,divided into severe adhesion group(32 cases)and the severe adhesion(58 cases).Physical examination work in the same period of 90 cases of healthy women in the control group.To detect all patients serum sICAM 1,resistance to seedling le tube hormone(AMH),follicle-stimu-lating hormone(FSH),luteinizing hormone(LH),estradiol(E2)levels and peripheral blood levels of Th17,SⅡ.Multiple Logistic regres-sion was used to analyze the relationship between sICAM-1,Th17,SⅡ and adhesion of severe ectopic endometrial cyst.Postoperative serum AMH,FSH,LH and E2 levels were compared between the severe adhesion group and the non-severe adhesion group,SICAM-1,Th17,SⅡ Pearson correlation analysis and the relationship between indicators of ovarian reserve function.Results:The levels of serum sICAM-1 and Th17 in peripheral blood in observation group were higher than those in control group,and SⅡ was higher than those in control group(P＜0.05).Serum sICAM-1 and peripheral blood Th17 levels in severe adhesion group were higher than those in non-severe adhesion group,SⅡ was higher than that in non-severe adhesion group(P＜0.05).Multiple Logistic regression analysis showed that sICAM-l,Th17 and SⅡ were all independent influencing factors of severe ectopic endometrial cyst adhesion(P＜0.05).Postoperative serum AMH and E2 levels were lower than the non-severe group,and FSH and LH levels were higher than the non-severe group(P＜0.05).Pearson correlation analysis showed that sICAM-1,Th17 and SⅡ in patients with endometriosis cyst were negatively correlated with post-operative AMH and E2(P＜0.05),and positively correlated with FSH and LH(P＜0.05).Conclusion:Serum sICAM-1,Th17 and SⅡ are positively correlated with the adhesion degree of endometriosis cyst,which is helpful to reflect the postoperative ovarian reserve function and worthy of further study and application.
Endometriosis cystSoluble adhesion molecule-1Helper T cell 17Systemic immune inflammatory indexDegree of adhesionOvarian reserve function
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