Correlation between the Expression of SCCAg and β-catenin and Pathological Features in Patients with Sinonasal Inverted Papilloma
Objective:To analyze patients with inverted papilloma of the nasal sinuses turn sexual squamous cell carcinoma anti-gen(SCCAg),β serial(β-catenin)protein expression and pathological characteristics of relevance.Methods:Select our hospital from January 2017 to December 2022,92 cases of patients with inverted papilloma of the nasal sinuses turn sex into the observation group,choose 92 cases of nasal inflammation patients as control group.Test all of the patients serum squamous cell carcinoma antigen(SCCAg),β serial protein expression level(β-catenin),analysis of different Krouse stage,tumor size,tumor pathological classification of patients with inverted papilloma of the nasal sinuses turn sexual serum SCCAg,β-catenin expression level.Use the receiver-operating characteristic curve(ROC)analysis of serum SCCAg,β-catenin in patients with inverted papilloma of the nasal sinuses turn sexual pre-diction effectiveness of postoperative recurrence.Results:Observation group serum SCCAg,β-catenin expression levels were higher than control group(P＜0.05).Serum T3 and T4 group SCCAg,β-catenin expression levels were higher than Tl,T2 group(P＜0.05).Tumor size or greater 20 groups of serum SCCAg cm3,β-catenin expression levels were higher than the tumor volume＜20 cubic cm group(P＜0.05).Hy-perplasia of active groups of serum SCCAg,hyperplasia of β-catenin expression levels were higher than the active group(P＜0.05).ROC analysis showed that serum SCCAg combined with β-catenin had a sensitivity of 91.45％,specifiicity of 52.38％and AUC of 0.928 in predicting postoperative recurrence in patients with inverted papilloma of nasal cavity and sinuses.Conclusion:Patients with inverted pa-pilloma of the nasal sinuses turn sexual serum SCCAg,β-catenin expression levels were significantly elevated,the two different Krouse stage,tumor size,tumor pathological classification of clear difference among patients,joint can increase the efficiency of the prediction of postoperative recurrence.
Inverted papilloma of nasal cavity and sinusesSquamous cell carcinoma antigenβ-cateninPathological featuresPost-operative recurrence
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