Predictive Value of High-Resolution CT Emphysema Index Combined with Serum CEA,NLR and PLR for the Risk of Non-Small Cell Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
Objective:To analyze the predictive value of high-resolution CT(HRCT)emphysema index combined with serum car-cinoembryonic antigen(CEA),neutrophil/lymphocyte(NLR),platelet/lymphocyte(PLR)on the risk of non-small cell lung cancer(NSCLC)in patients with chronic obstructive pulmonary disease(COPD).Methods:Selected 120 patients with COPD complicated with NSCLC who were admitted to Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital from June 2020 to March 2023 were selected as combined group,80 patients with NSCLC alone were selected as NSCLC group,and 80 patients with COPD alone were selected as COPD group.The HRCT emphysema indexes[emphysema index(EI),emphysema Goddard score],CEA,NLR,PLR were compared among three groups.The value of HRCT emphysema index,CEA,NLR and PLR in predicting the risk of NSCLC in COPD patients were analyzed by receiver operating characteristic(ROC)curve.Results:Serum levels of CEA,NLR,and PLR were greater in combined group than in NSCLC group and COPD group,with NSCLC group had higher levels than COPD group(P＜0.05).The combined group's Goddard score and EI were greater than those in COPD group and NSCLC group,and COPD group was higher than NSCLC group(P＜0.05).ROC curve showed that,the area under the ROC curve(AUC)of CEA,NLR,PLR,Goddard score,EI and the combination of the five in predicting the occurrence of COPD combined with NSCLC was 0.833,0.835,0.771,0.824,0.813 and 0.991,respectively.Conclusion:HRCT emphysema index and serum CEA,NLR and PLR are increase in COPD patients with NSCLC.HRCT emphysema index combined with CEA,NLR and PLR can effectively predict the occurrence of COPD combined with NSCLC.
NETL
NSTL
万方数据
