Study on the Clinical Value of Serum FGF-21 and FGF-23 Detection in Patients with Sepsis Combined with Acute Kidney Injury
Objective:To study the clinical value of serum fibroblast growth factor-21(FGF-21)and fibroblast growth factor-23(FGF-23)detection in patients with sepsis combined with acute kidney injury(AKI).Methods:202 patients with sepsis admitted to Baiyun Hospital Affiliated to Guizhou Medical University and the Affiliated Hospital of Guizhou Medical University from May 2020 to August 2023 were selected,and patients were divided into non-AKI group(n=109)and AKI group(n=93)according to whether they were combine with AKI,70 healthy volunteers who underwent physical examinations in our hospital were selected as health group during the same period.Patients were divided into death group and survival group according to the 28-day clinical outcome of patients with sepsis combine with AKI.Serum FGF-21 and FGF-23 levels were detected.The influencing factors of 28-day death in patients with sepsis combine with AKI were analyzed by multivariate Logistic regression model,the predictive value of serum FGF-21 and FGF-23 for 28-day death in patients with sepsis combined with AKI were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with healthy group,the levels of serum FGF-21 and FGF-23 in non-AKI group and the AKI group were significantly increased(P＜0.05).Compared with non-AKI group,the serum levels of FGF-21 and FGF-23 in AKI group were significantly increased(P＜0.05).Among 93 patients with sepsis combined with AKI,26 died within 28 days,with a mortality rate of 27.96％.Compared with survival group,the serum FGF-21 and serum FGF-23 in death group were significantly increased(P＜0.05).Multivariate Logistic regression analysis showed that AKI stage Ⅱ～Ⅲ,increased APACHE Ⅱ score,increased SOFA score,increased serum FGF-21 and increased serum FGF-23 were risk factors for 28-day death in patients with sepsis combine with AKI(P＜0.05).ROC curve results showed that,the AUC,sensitivity and specificity of FGF-21 combine with FGF-23 in predicting 28-day death in patients with sepsis combine with AKI were 0.798,0.769 and 0.791 respectively,which were significantly better than those of single detection.Conclusion:Serum FGF-21 and FGF-23 are highly express in patients with sepsis combined with AKI,which are relate to 28 deaths in patients with sepsis combined with AKI.The combined detection of serum FGF-21 and FGF-23 has a high predictive value for 28-day death in patients with sepsis combined with AKI.
SepsisAcute kidney injuryFibroblast growth factor-21Fibroblast growth factor-23Clinical value
NETL
NSTL
万方数据
