Clinical Significance Analysis of Tendon Glycoprotein C,Triglyceride Glucose Index,and Serum Osteosclerosis Protein in Maintenance Hemodialysis Complicated with Cardiovascular Events
Objective:To explore the diagnostic significance and prognostic value of Tendon glycoprotein C(TN-C),Triacylglycerol glucose index(TyG),and serum osteosclerosis protein(SOST)in maintenance hemodialysis with cardiovascular events.Method:80 patients with maintenance hemodialysis complicated with cardiovascular events admitted to our hospital from January 2020 to January 2023 were selected as the study subjects and divided into an observation group.In addition,80 patients without cardiovascular events admitted to maintenance hemodialysis during the same period were selected as the control group.Compare the expression levels of TN-C,TyG,and SOST between two groups of patients,and establish receiver operating characteristic(ROC)curves to analyze the diagnostic efficacy of TN-C,TyG,and SOST for cardiovascular events in hemodialysis patients.Follow up all patients,record the mortality caused by cardiovascular events during the follow-up process,and divide the deceased patients into a poor prognosis group(n=25)and the remaining patients into a good prognosis group(n=55).Compare their clinical related data and use logistic regression models to analyze the predictive value of TN-C,TyG,and SOST for the prognosis of maintenance hemodialysis combined with cardiovascular events.Result:There was a significant difference in TN-C,TyG,and SOST levels between the two groups of patients,with the observation group significantly higher than the control group(P＜0.05);The area under the diagnostic curve of the three combined NSE for hemodialysis combined with cardiovascular events is 0.897,and the sensitivity and specificity are significantly higher than single indicators(P＜0.05);There was no significant difference in gender,BMI,and comorbidities between the group with good prognosis and the group with poor prognosis(P＞0.05).However,there were significant differences in age,dialysis time,alcohol consumption history,smoking history,TN-C,TyG,and SOST levels between the group with good prognosis and the group with poor prognosis(P＜0.05);The results of logistic regression analysis showed that age,TN-C,TyG,and SOST were independent predictive factors for the prognosis of cardiovascular events in maintenance hemodialysis(P＜0.05).Conclusion:TN-C,TyG,and SOST have important value in the diagnosis and prognosis prediction of cardiovascular events in maintenance hemodialysis,and their combination can improve the diagnostic efficacy of cardiovascular events in maintenance hemodialysis.
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