Clinical Characteristics and Related Factors Analysis of Influenza Virus Combined with Streptococcus Pneumoniae Infection in Children
Objective:To investigate the clinical characteristics and related factors of influenza virus combined with streptococcus pneumoniae infection in children.Methods:A retrospective analysis was conducted on 70 children with influenza virus combined with streptococcus pneumoniae infection admitted to our hospital from December 2020 to November 2023.They were divided into an observation group and another 70 children with simple influenza virus infection who were treated in our hospital during the same period were selected as the control group.The clinical characteristics of the two groups of children were compared,and the drug sensitivity test of 70 children with influenza virus combined with streptococcus pneumoniae infection was analyzed.The prognosis and incidence of complications were compared between the observation group and the control group.Finally,a logistic regression model was used to analyze the risk factors of influenza virus combined with streptococcus pneumoniae infection in children as the dependent variable(combined with streptococcus pneumoniae infection=l,not combined with streptococcus pneumoniae infection=0).Results:There was no significant difference in gender,peak fever,high fever,convulsive symptoms,and influenza vaccine administration between the observation group and the control group(P＞0.05).However,there were significant differences in age,influenza virus infection duration,fever duration,wet rales,consciousness disorders,shortness of breath,wheezing symptoms,pneumococcal vaccine administration,elevated neutrophils,white blood cell count(WBC),C-reactive protein(CRP),and procalcitonin(PCT)levels between the observation group and the control group(P＜0.05);A total of 70 Streptococcus pneumoniae strains isolated from the observation group showed higher sensitivity to cefotaxime,penicillin,ceftriaxone,vancomycin,linezolid,ertapenem,thalimycin,and levofloxacin,and lower sensitivity to cotrimoxazole,tetracycline,meropenem,and erythromycin;Elevated neutrophils,elevated CRP,and elevated PCT are risk factors for influenza virus associated streptococcus pneumoniae infection in children,while pneumococcal vaccination is a protective factor(P＜0.05).Conclusion:Compared with simple influenza virus infection,influenza virus combined with streptococcus pneumoniae infection in children has a longer course of disease,with specific symptoms such as wet rales,consciousness disorders,shortness of breath,and wheezing.The incidence of complications is higher,and the prognosis is poor.It is accompanied by elevated neutrophils,WBC,CRP,and PCT levels,and sensitivity to cefotaxime,penicillin,ceftriaxone,vancomycin,linezolid,ertapenem,telimacin,and levofloxacin.Further analysis shows that elevated neutrophils,elevated CRP,and elevated PCT are risk factors for influenza virus combined with streptococcus pneumoniae infection in children,and pneumococcal vaccination is a protective factor.
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