Three Acyl Glycerin,Oxidized Modified Low Density Lipoprotein and Placental Growth Factor with Preeclampsia Progress and Study the Relationship between the Risk of Spontaneous Abortion
Objective:Analysis of serum three acyl glycerin(TAG),oxidized modified low density lipoprotein(OX-LDL)and placental growth factor(PLGF)with preeclampsia disease progression and the relationship between the risk of spontaneous abortion.Methods:A total of 120 pregnant women with preeclampsia(observation group)and 120 pregnant women with normal pregnancy test results(control group)admitted to our hospital from February 2022 to February 2023 were selected as research objects.The expression levels of serum TAG,OX-LDL and PLGF in all pregnant women were detected,and the progress of preeclampsia was recorded.More progress with stable condition group TAG,OX-LDL,serum PLGF expression level indicators and uterine artery blood flow mechanics.Using multiariable Logistic regression analysis of serum TAG,OX-LDL,PLGF and preeclampsia progression,the relationship between the receiver-operating characteristic curve(ROC)analysis of serum TAG,OX-LDL and PLGF to preeclampsia prediction to miscarry.Results:Observation group TAG,OX-LDL is higher than the control group,serum PLGF level lower than the control group,(P＜0.05).Progression group serum TAG,OX-LDL level group were higher than in a stable condition and PLGF level under stable condition group(P＜0.05).The multi-factor Logistic regression analysis,TAG,OX-LDL,serum PLGF were preeclampsia is an independent predictor of disease progression(P＜0.05).Progression group of uterine artery pulsation index(PI),resistance index(RI),systolic and diastolic blood flow velocity ratio(S/D)were greater than in a stable condition group(P＜0.05).The Pearson correlation analysis,preeclampsia pregnant uterine artery PI,RI and S/D and serum TAG,OX-LDL expression levels were positively correlated(P＜0.05),and negatively correlated to the level of PLGF(P＜0.05).According to ROC curve analysis,the AUC of serum TAG,OX-LDL combined with PLGF in predicting abortion of preeclampsia pregnant women was 0.908,which was greater than 0.648 of TAG,0.660 of OX-LDL and 0.673 of PLGF(P＜0.05).Conclusion:Serum TAG,OX-LDL and PLGF are closely related to the progression of preeclampsia.The combined application has a certain predictive value for abortion and is worthy of clinical attention.
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