Study on the Diagnostic Value of Contrast-Enhanced Ultrasound Combined with Serum Intestinal Trefoil Factor in Non-Small Cell Lung Cancer
Objective:To investigate the diagnostic value of contrast-enhanced ultrasound combined with serum intestinal trefoil factor(ITF)in non-small cell lung cancer(NSCLC).Methods:From January 2021 to June 2023,130 patients with pulmonary space-occupying lesions who underwent surgical treatment in our hospital were included as the study subjects.All patients underwent contrast-enhanced ultrasonography and serum ITF detection before operation.According to the postoperative pathological results,the patients were divided into NSCLC group(n=58)and benign lung tumor group(n=72).Contrast-enhanced ultrasound parameters and serum ITF levels were compared between the two groups.The receiver operating characteristic curve(ROC)was drawn to analyze the diagnostic value of contrast-enhanced ultrasound parameters,serum ITF and their combination for NSCLC.Results:RT,TP,AT2 and△AT in NSCLC group were higher than those in benign lung tumor group(P＜0.05).The level of serum ITF in NSCLC group was higher than that in benign lung tumor group(P＜0.05).The results of ROC curve analysis of contrast-enhanced ultrasound parameters showed that the largest area under the curve(AUC)was△ AT,and when △AT ≥ 3.14s,its specificity was 88.29％,which had high diagnostic value for NSCLC.ROC curve analysis of serum ITF showed that AUC was 0.735,and when serum ITF≥ 1073.82 pg/mL,its specificity was 81.06％,which had certain diagnostic value for NSCLC.The ROC curve analysis of contrast-enhanced ultrasound parameters combined with serum ITF showed that the AUC was 0.916 and the specificity was 91.20％,which had the best diagnostic value for NSCLC.Conclusion:Contrast-enhanced ultrasound combined with serum ITF has a high diagnostic value for NSCLC,which is helpful for the differential diagnosis of benign and malignant lung tumors,and provides a reliable reference for the clinical diagnosis and treatment of patients.
Contrast-enhanced ultrasoundIntestinal trefoil factorNon-small cell lung cancerDiagnostic value
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