Study on the Relationship between USP18,USP20,USP25 and Clinicopathological Features and Prognosis in Female Breast Invasive Ductal Carcinoma
Objective:To investigate the relationship between the expression of ubiquitin-specific protease 18(USP18),ubiquitin-specific protease 20(USP20),ubiquitin-specific protease 25(USP25)and clinicopathological features and prognosis in female breast invasive ductal carcinoma.Methods:98 female patients with breast invasive ductal carcinoma admitted to Sichuan Provincial Maternity and Child Health Care Hospital and Ya'an People's Hospital from March 2017 to March 2020 were selected as the research objects,the expression of USP18,USP20 and USP25 in breast invasive ductal carcinoma tissues and adjacent tissues was detected by immunohistochemical methods,and the relationship between the expression of USP18,USP20 and USP25 in cancer tissues and clinicopathological features was analyzed.The independent risk factors for the prognosis of female breast invasive ductal carcinoma were analyzed by multivariat Logistic regression.The difference in prognosis between patients with negative and positive expression of USP18,USP20 and USP25 were analyzed by Kaplan-Meier survival curve.Results:The positive expression rates of USP20,USP18 and USP25 in breast invasive ductal carcinoma tissues were higher than those in adjacent tissues(P＜0.05).The positive expression of USP20 in breast invasive ductal carcinoma was related to the degree of differentiation and TNM stage(P＜0.05).The positive expression of USP18 was correlated with TNM stage,lymph node metastasis,molecular subtype and differentiation degree(P＜0.05).The positive expression of USP25 was related to lymph node metastasis and differentiation(P＜0.05).Multivariate Logistic regression analysis showed that lymph node metastasis,TNM stage Ⅲ,positive expression of USP18,positive expression of USP20 and positive expression of USP25 were independent risk factors affecting the prognosis of patients(P＜0.05).Kaplan-Meier survival curve showed that the 3-year recurrence-free survival rates of patients with positive expression of USP18,USP20 and USP25 were 59.65％,59.32％and 58.62％respectively,which were lower than 82.05％,83.78％and 84.21％of patients with negative expression of USP18,USP20 and USP25 respectively.Conclusion:The expression of USP18,USP20,and USP25 in invasive ductal carcinoma of the female breast is closely related to lymph node metastasis,TNM staging,differentiation degree,and molecular subtypes.Positive expression of USP18,USP20,and USP25 is an independent risk factor affecting patient prognosis and is associated with a 3-year recurrence free survival rate.
Breast invasive ductal carcinomaUSP18USP20USP25Clinicopathologic featuresPrognosis
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