Diagnostic Value of Liver Shear Wave Elastography Combined with FIB-4 Index,Serum GP73 and CHI3L1 for Liver Fibrosis in Patients with Chronic Hepatitis B
Objective:To investigate the diagnostic value of liver shear wave elastography combined with fibrosis index based on factor 4(FIB-4),serum Golgi protein 73(GP73)and chitinase 3-like protein 1(CHI3L1)for liver fibrosis in patients with chronic hepati-tis B(CHB).Methods:186 CHB patients admitted to The Fifth Medical Center of People's Liberation Army General Hospital from June 2020 to December 2022 were selected,and patients were divided into significant liver fibrosis group(116 cases)and non-significant liver fibrosis group(70 cases)based on liver fibrosis stage.All CHB patients underwent liver shear wave elastography to obtain liver shear wave elastography parameters,evaluate FIB-4 index,and detect serum GP73 and CHI3L1 levels.The value of liver shear wave elastogra-phy parameters combine with FIB-4 index,serum GP73 and CHI3L1 in diagnosing significant liver fibrosis in CHB patients were ana-lyzed by receiver operating characteristic(ROC)curve.Results:Max,Mean,Min,FIB-4 index,serum GP73 and CHI3L1 levels in signif-icant liver fibrosis group were higher than those in non-significant liver fibrosis group(P＜0.05).The area under the curve of Max,Mean,Min,FIB-4,GP73 and CHI3L1 in the diagnosis of significant liver fibrosis in CHB patients was 0.801,0.773,0.708,0.795,0.788 and 0.783 respectively,the area under the curve of combined diagnosis was 0.905,which was higher than that of single diagnosis.Conclu-sion:The levels of Max,Mean,Min,FIB-4 index,serum GP73 and CHI3L1 in patients with significant liver fibrosis in CHB are increase,liver shear wave elastography parameters combined with FIB-4 index,serum GP73 and CHI3L1 can improve the efficacy in diagnosing significant liver fibrosis in CHB patients.
Chronic hepatitis BLiver fibrosisShear wave elastographyFIB-4 indexGP73CHI3L1Diagnostic value
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