Study on the Relationship between Serum Hcy,SOD,SDF-1 and Distal Symmetric Polyneuropathy in Patients with Type 2 Diabetes Mellitus
Objective:To analyze the relationship between serum homocysteine(Hcy),superoxide dismutase(SOD),stromal cell-derived factor-1(SDF-1)and distal symmetric polyneuropathy(DSPN)in patients with type 2 diabetes mellitus(T2DM).Methods:146 T2DM patients admitted to our hospital from January 2020 to January 2023 were selected as research objects,ccording to whether they were combined with DSPN,patients were divided into DSPN(DSPN group)and non-DSPN(NDSPN group),65 cases and 81 cases respectively.The general clinical data(drinking history,smoking history,age,duration of diabetes mellitus,body mass index,baseline blood pressure,gender,etc.)and biochemical indexes such as blood glucose and blood lipid were collected.The levels of Hcy,SOD and SDF-1 in serum were detected by enzyme-linked immunosorbent assay,the levels of serum Hcy,SOD and SDF-1 were compared be-tween two groups,the levels of serum Hcy,SOD and SDF-1 in patients with different severity of disease were analyzed,the correlation between the three and the severity of DSPN was analyzed,and the predictive value of the three in the clinical diagnosis of DSPN were analyzed by receiver operating curve(ROC).Results:The age,duration of diabetes mellitus and DBP in DSPN group were higher than those in NDSPN group(P＜0.05).The serum SOD and SDF-1 levels in DSPN group were significantly lower than those in NDSPN group,while the Hcy level was significantly higher than that in NDSPN group(P＜0.05).The level of serum Hcy increased with the severity of DSPN neuropathy,while the levels of SOD and SDF-1 decreased with the severity of DSPN neuropathy(P＜0.05).Multivariate Logistic regression analysis showed that,age,duration of diabetes mellitus and serum levels of SOD,Hcy and SDF-1 were independent influenc-ing factors of DSPN(P＜0.05).The area under the curve(AUC)of serum Hcy,SOD and SDF-1 levels for predicting DSPN in T2DM pa-tients was 0.793,0.801 and 0.840 respectively,the AUC value of the combined prediction of the three(0.877)was higher than that of the three alone.Conclusion:Serum Hcy,SOD and SDF-1 may be involve in the occurrence and development of DSPN,which are indepen-dent influencing factors of DSPN,and joint testing have high predictive value for the clinical diagnosis of DSPN.
Type 2 diabetes mellitusHcySODSDF-1Distal symmetric polyneuropathy
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NSTL
万方数据
