Correlation Analysis of TyG Index,Serum Gal-3,HDAC3 and the Risk of Cerebral Ischemic Stroke in Patients with Non-Valvular Atrial Fibrillation
Objective:To investigate the correlation between triglyceride glucose(TyG)index,serum galectin-3(Gal-3),histone deacetylase 3(HDAC3)and the risk of cerebral ischemic stroke(CIS)in patients with non-valvular atrial fibrillation(NVAF).Methods:347 NVAF patients admitted to China Resources WISCO General Hospital Affiliated to Wuhan University of Science and Technology from January 2022 to September 2022 were selected as research objects,all patients were followed up for 1 year,patients were divided into CIS group and non-CIS group according to whether CIS occurred during the follow-up period.Serum Gal-3 and HDAC3 levels were detected by enzyme-linked immunosorbent assay,and TyG index was calculated.The influencing factors of CIS in NVAF patients were analyzed by multivariate Logistics regression analysis,the predictive value of TyG index and serum Gal-3 and HDAC3 for CIS in NVAF patients were analyzed by receiver operating characteristic(ROC)curve.Results:After 1 year of follow-up,the incidence of CIS in NVAF patients was 22.77％(79/347).The TyG index,serum Gal-3 and HDAC3 levels in CIS group were higher than those in non-CIS group(P＜0.05).Multivariate Logistics regression analysis showed that,the elevated of CHA2DS2-VASC score,left atrial dimension(LAD),TyG index,Gal-3 and HDAC3 were independent risk factors for CIS in NVAF patients(P＜0.05),and elevated LVEF was protec-tive factor for CIS in NVAF patients(P＜0.05).The area under the curve(AUC)of TyG index,Gal-3 and HDAC3 in predicting CIS in NVAF was 0.631,0.790 and 0.769 respectively,and the AUC of combined prediction was 0.918.Conclusion:The increase of TyG in-dex,serum Gal-3 and HDAC3 are independent risk factors for CIS in NVAF patients,the combine detection of TyG index,serum Gal-3 and HDAC3 has a high predictive value for CIS risk in NVAF patients.
Non-valvular atrial fibrillationCerebral ischemic strokeTyG indexGal-3HDAC3Predictive value
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