Effects of Hyperbaric Oxygen Combined with Alteplase Intravenous Thrombolysis on Cerebral Blood Perfusion Status and Serum IMA,NFL and Occludin Levels in Patients with Acute Ischemic Stroke
Objective:To investigate the effects of hyperbaric oxygen combined with alteplase intravenous thrombolysis on cere-bral blood perfusion status and serum ischaemic modified albumin(IMA),neurofilament light chain protein(NFL)and Occludin levels in patients with acute ischemic stroke(AIS).Methods:124 patients with AIS in our hospital from June 2022 to June 2023 were selected as the study objects,and were randomly divided into control group and observation group,62 cases in each group.The control group was given alteplase intravenous thrombolysis therapy,and the observation group was given hyperbaric oxygen therapy on the basis of the con-trol group.The clinical efficacy,National institute of Health Stroke Scale(NHISS)and modified Rankin scale(mRS)score,cerebral per-fusion status[cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT),time to peak(TMax)],serum IMA,NFL,Occludin levels and incidence of adverse reactions were compared between the two groups.Results:Compared with control group,the total effective rate of observation group was higher,NHISS and mRS score were decreased after 2 weeks of treatment(P＜0.05).Com-pared with control group,CBF and CBV were increased and MTT and TMax were shortened in observation group after 2 weeks of treat-ment(P＜0.05).Compared with control group,serum IMA,Occludin and NFL levels in observation group decreased after 2 weeks of treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclu-sion:Hyperbaric oxygen combined with alteplase intravenous thrombolytic therapy for AIS patients can improve cerebral blood perfu-sion,reduce serum IMA,Occludin and NFL levels,and alleviate nerve function injury,with significant efficacy and high safety.
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