Effects of Runzao Zhiyang Capsules Combined with Tacalcitol Ointment on Immune Inflammatory Response and Intestinal Microecology in Patients with Psoriasis Vulgaris
Objective:To observe the effects of combined treatment of runzao zhiyang capsule and tacalcitol ointment on immune inflammatory response and intestinal microecology in patients with psoriasis vulgaris.Methods:Patients with psoriasis vulgaris admitted to Suzhou Hospital Affiliated to Anhui Medical University from March 2021 to December 2022 were selected,a total of 124 cases.Pa-tients were divided into control group(treated with tacalcitol ointment)and combined group(treated with runzao zhiyang capsule com-bine with tacalcitol ointment)according to the random number method,with 62 cases in each group.The efficacy,clinical symptom scores,immune function indicators,inflammatory indexes and intestinal microecological indexes were compared between two groups.And the safety in two groups was recorded.Results:Compared with control group,the total clinical effective rate in combined group was higher(P＜0.05).Compared with control group after treatment,the Escherichia Coli,Enterococcus,psoriasis area and severity index(PASI)score,CD8+,interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),and IL-8 in combined group were lower,and the dermatol-ogy life quality index(DLQI)score,Lactobacillus,Bifidobacterium,Yeast,CD3+,CD4+and CD4+/CD8+were higher(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Patients with psoriasis vulgaris combined with runzao zhiyang capsule on the basis of tacalcitol ointment treatment,which can effectively improve the clinical symptoms of patients,regulate immune inflammatory response and intestinal microecology,and have good safety.
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