Estimating the Relationship between Pulse wave Velocity and Cardiovascular Diseases in Chinese Middle-aged and Elderly People
Objective:To investigate the relationship between estimated pulse wave velocity(ePWV)and cardiovascular and cere-brovascular diseases in middle-aged and elderly people in China's community.Methods:Middle-aged and elderly people from the first wave of China Health and Retirement Longitudinal Study(CHARLS)in 2011-2012 were selected for this study.General information and laboratory indicators of the population were collected,and the differences in clinical information between the groups were compared.Lo-gistic regression analysis was used to investigate the effect of ePWV on the risk of cardiovascular disease.Results:A total of 9,542 study subjects were included in this study,of which a total of 1,348 patients suffered from cardiovascular and cerebrovascular diseases.ePWV was significantly associated with the prevalence of cardiovascular and cerebrovascular diseases,both as a continuous and categorical variable,in the adjusted multivariate logistic regression analysis model.When used as a continuous variable,each 1 unit increase in eP-WV was associated with an 8％increase in the prevalence of cardiovascular and cerebrovascular disease(OR=1.08,95％CI:1.02-1.14,P=0.008).Subgroup analysis showed that ePWV was significantly associated with cardiovascular and cerebrovascular diseases in the sub-groups of age＜60 years,less than high school education,and married.ePWV was not significantly associated with cardiovascular and cerebrovascular diseases in the subgroups of age＞60 years,females,smokers,alcohol consumption(never vs.1 time per month vs.＜1 time per month),and BMI(＜25 vs.≥ 25).Conclusion:ePWV is an independent risk factor for cardiovascular and cerebrovascular dis-eases in the middle-aged and elderly population in China,and can be used as an indicator for primary prevention and monitoring of car-diovascular and cerebrovascular diseases in the future,but more studies are still needed to confirm this.
Cardiovascular and cerebrovascular diseasesEstimating pulse wave velocityAtherosclerosisMiddleaged and elderly
NETL
NSTL
万方数据
