估计脉搏波速度与中国中老年人心脑血管疾病的关系
Estimating the Relationship between Pulse wave Velocity and Cardiovascular Diseases in Chinese Middle-aged and Elderly People
潘锦滨 1张土明 1陈建英 2张兴斌 1吴柱国3
作者信息
- 1. 广东医科大学第一临床医学院 广东湛江 524000;广东医科大学附属医院心血管内科 广东湛江 524000
- 2. 广东医科大学附属医院心血管内科 广东湛江 524000
- 3. 广东医科大学附属东莞第一医院心血管内科 广东东莞 320560
- 折叠
摘要
目的:探究估计脉搏波速度(ePWV)与我国社区中老年人心脑血管疾病的关系.方法:选取2011年-2012年第一波中国健康与养老追踪调查(CHARLS)的中老年人纳入本研究.收集人群一般资料及实验室指标,比较各组临床资料的差异.采用logistic回归分析探究ePWV对心脑血管疾病患病风险的影响.结果:共9542例研究对象纳入本研究,其中共1348例患者患有心脑血管疾病,在调整多变量的logistic回归分析模型中,无论作为连续变量还是分类变量,ePWV都与心脑血管疾病患病率显著相关.作为连续变量时,ePWV每增加1个单位,心脑血管疾病患病率增加8％(OR=1.08,95％CI:1.02-1.14,P=0.008).亚组分析显示,在年龄＜60岁、高中以下学历、已婚的亚组中,ePWV与心脑血管疾病关系显著,在年龄＞60岁、女性、吸烟、饮酒(从不饮酒vs每月1次vs每月＜1次)、BMI(＜25vs≥25),ePWV与心脑血管疾病关系不显著.结论:ePWV是中国中老年人群心脑血管疾病的独立危险因素,可作为未来心脑血管疾病一级预防和监测的指标,但仍需更多的研究证实.
Abstract
Objective:To investigate the relationship between estimated pulse wave velocity(ePWV)and cardiovascular and cere-brovascular diseases in middle-aged and elderly people in China's community.Methods:Middle-aged and elderly people from the first wave of China Health and Retirement Longitudinal Study(CHARLS)in 2011-2012 were selected for this study.General information and laboratory indicators of the population were collected,and the differences in clinical information between the groups were compared.Lo-gistic regression analysis was used to investigate the effect of ePWV on the risk of cardiovascular disease.Results:A total of 9,542 study subjects were included in this study,of which a total of 1,348 patients suffered from cardiovascular and cerebrovascular diseases.ePWV was significantly associated with the prevalence of cardiovascular and cerebrovascular diseases,both as a continuous and categorical variable,in the adjusted multivariate logistic regression analysis model.When used as a continuous variable,each 1 unit increase in eP-WV was associated with an 8％increase in the prevalence of cardiovascular and cerebrovascular disease(OR=1.08,95％CI:1.02-1.14,P=0.008).Subgroup analysis showed that ePWV was significantly associated with cardiovascular and cerebrovascular diseases in the sub-groups of age＜60 years,less than high school education,and married.ePWV was not significantly associated with cardiovascular and cerebrovascular diseases in the subgroups of age＞60 years,females,smokers,alcohol consumption(never vs.1 time per month vs.＜1 time per month),and BMI(＜25 vs.≥ 25).Conclusion:ePWV is an independent risk factor for cardiovascular and cerebrovascular dis-eases in the middle-aged and elderly population in China,and can be used as an indicator for primary prevention and monitoring of car-diovascular and cerebrovascular diseases in the future,but more studies are still needed to confirm this.
关键词
心脑血管疾病/估计脉搏波速度/动脉硬化/中老年人Key words
Cardiovascular and cerebrovascular diseases/Estimating pulse wave velocity/Atherosclerosis/Middleaged and elderly引用本文复制引用
基金项目
国家自然科学基金项目(81370242)
广东医科大学学科建设项目(4SG23012G)
出版年
2024
NETL
NSTL
万方数据