Study on the Relationship between Serum SAA,PCT/Lac Ratio,CRP/Alb Ratio and Prognosis in Patients with Type 2 Diabetic Ketoacidosis Complicated with Infection
Objective:To investigate the relationship between serum amyloid A(SAA),procalcitonin(PCT)/blood lactic acid(Lac)ratio,C-reactive protein(CRP)/albumin(Alb)ratio and prognosis in patients with type 2 diabetic ketoacidosis complicated with in-fection.Methods:178 patients with type 2 diabetic ketoacidosis complicated with infection who were admitted to the General Hospital of Eastern Theater Command of Chinese People's Liberation Army from February 2020 to May 2023 were selected,patients were divided into survival group and death group according to the clinical outcome of 28 d after admission.The serum SAA,PCT/Lac ratio and CRP/Alb ratio were compared between two groups.The factors affecting the prognosis of patients with type 2 diabetic ketoacidosis com-plicated with infection were analyzed by multivariate logistic regression model,the value of serum SAA,PCT/Lac ratio and CRP/Alb ratio in predicting the prognosis of patients with type 2 diabetic ketoacidosis complicated with infection were analyzed by receiver operat-ing characteristic(ROC)curve.Results:28 d after admission,31 patients died,with a mortality rate of 17.42％.The serum SAA,PCT/Lac ratio and CRP/Alb ratio in death group were higher than those in survival group(P＜0.05).Multivariate Logistic regression analysis showed that,the severity of type 2 diabetic ketoacidosis,the increase of SAA level,the increase of PCT/Lac ratio and the increase of CRP/Alb ratio were the risk factors affecting the prognosis of patients with type 2 diabetic ketoacidosis complicated with infection(P＜0.05).ROC curve analysis showed that,the area under the curve(AUC)of serum SAA,PCT/Lac ratio,CRP/Alb ratio and their combination in predicting the prognosis of patients with type 2 diabetic ketoacidosis complicated with infection were 0.781,0.704,0.852 and 0.901,respectively.Conclusion:Serum SAA,PCT/Lac ratio and CRP/Alb ratio of patients with type 2 diabetic ketoacidosis complicated with infection increased,and they are risk factors for the prognosis of patients.The combination of serum SAA,PCT/Lac ratio and CRP/Alb ratio has a higher predictive value for the prognosis of patients with type 2 diabetic ketoacidosis complicated with infection.
Type 2 diabeticKetoacidosisInfectionAmyloid AProcalcitonin/Blood lactic acid ratioC-reactive protein/Albumin ratioPrognosis
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