The Correlation between Serum VEGF,ATⅡ,and NE Levels and the Malignancy of Pituitary Tumors and their Prognostic Value Analysis
Objective:To explore the correlation between serum vascular endothelial growth factor(VEGF),angiotensin Ⅱ(AT Ⅱ),and norepinephrine(NE)with the malignancy of pituitary tumors and their prognostic value.Methods:80 patients with pituitary tumors admitted to our hospital from January 2018 to January 2021 were selected as the research subjects.20 patients diagnosed with invasive malignant pituitary tumors by pathological diagnosis were divided into the malignant group,the remaining 60 patients with benign pitu-itary tumors were divided into the benign group,and 40 healthy individuals who came to our hospital for physical examination during the same period were selected as the control group.Compare the expression levels of serum VEGF,ATⅡ,and NE among three groups of subjects,and use Spearman correlation analysis to analyze the correlation between serum VEGF,ATⅡ,and NE and the malignancy of pituitary tumors.Subsequently,80 patients with pituitary tumors were followed up for 3 years.The occurrence of new metastases,relapses,and death was considered as poor prognosis.Based on the prognosis,the 80 patients with pituitary tumors were divided into two sub-groups,namely the poor prognosis group(n=23)and the good prognosis group(n=57).Logistic regression models were used to analyze the independent prognostic factors of pituitary tumors.Results:There were significant differences in the expression levels of serum VEGF,ATⅡ,and NE among the three groups of subjects.The malignant group was higher than the benign group and the control group(P＜0.05);The Spearman correlation analysis results showed that serum VEGF,ATⅡ,and NE were positively correlated with the malig-nancy of pituitary tumors(P＜0.05);There was no significant difference in gender,age,tumor size,concurrent cystic changes,and optic nerve compression between the group with good prognosis and the group with poor prognosis(P＞0.05).However,there was a significant difference in invasive tumors,concurrent tumor stroke,and serum VEGF,ATⅡ,and NE levels between the group with good prognosis and the group with poor prognosis(P＜0.05);Invasive tumors,elevated levels of serum VEGF,ATⅡ,and NE are independent influencing factors for poor prognosis of pituitary tumors(P＜0.05).Conclusion:VEGF,ATⅡ,and NE are positively correlated with the malignancy of pituitary tumors,and invasive tumors and elevated serum VEGF,ATⅡ,and NE levels are independent influencing factors for poor prog-nosis of pituitary tumors.In clinical practice,it is necessary to improve treatment measures for patients with invasive tumors and those with elevated serum VEGF,ATⅡ,and NE levels to prevent poor prognosis.
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