Study on the Relationship between High-Resolution CT Typing and Airway Inflammation,Immune Function,and Clinical Efficacy in COPD Patients
Objective:To study the relationship between high-resolution CT(HRCT)typing and airway inflammation,immune function and clinical efficacy in patients with chronic obstructive pulmonary disease(COPD).Methods:165 COPD patients admitted to the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University from May 2020 to August 2023 were selected,and patients were divided into type A group(n=81),type E group(n=46)and type M group(n=38)according to HRCT imaging phenotype.Pulmonary function indexes[forced expiratory volume in the first second(FEV1),percentage of forced expiratory volume in the first second to predicted value(FEV1％),forced expiratory volume in the first second/forced vital capacity(FEV1/FVC),residual volume/total lung capacity(RV/TLC)],airway inflammation indexes[C-reactive protein(CRP),interleukin-6(IL-6)],immune function indexes and clinical efficacy were compared in each group.Results:FEV1,FEV1％and FEV1/FVC in type E group and M group were lower than those in type A group,and type M group were lower than those of type E group(P＜0.05).RV/TLC in type E group and type M group was higher than that in type A group,and RV/TLC in type M group was higher than that in type E group(P＜0.05).The levels of CRP and IL-6 in type A group and type E group were lower than those in type M group,and type E group were lower than those of type A group(P＜0.05).CD3+and CD4+/CD8+in type E group and type M group were lower than those in type A group,and type M group were lower than those of type E group(P＜0.05).The total effective rate in group A was higher than that in type E group and type M group,and type E group was higher than that of type M group(P＜0.05).Conclusion:There are great differences in airway inflammation,immune function and clinical efficacy among COPD patients with different HRCT types,this situation can be paid attention to in the process of diagnosis and treatment,so as to provide support for clinical diagnosis and treatment.
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