Effects of Erector Spinae Plane Block and Local Infiltration Anesthesia on Analgesic Effect,Stress Response and Inflammatory Response in Elderly Patients Undergoing PKP Operation
Objective:To observe the effects of erector spinae plane block(ESPB)and local infiltration anesthesia on analgesic effect,stress response and inflammatory response in elderly patients undergoing balloon kyphoplasty(PKP)operation.Methods:110 elderly patients undergoing PKP operation who were admitted to our hospital from April 2020 to April 2023 were selected.According to the random number table method,patients were divided into control group(receiving local infiltration anesthesia)and experimental group(receiving ESPB),55 cases in each group.The hemodynamics,pain visual analogue scale(VAS),stress response and inflammatory response were compared in two groups,and incidence of adverse reactions was observed in two groups.Results:Mean arterial pressure(MAP)and heart rate(HR)in two groups increased first and then decreased from the time of puncture(T1)to the time before the end of operation(T4),and experimental group were lower than those of control group at the same time(P＜0.05).The VAS scores in two groups increased and then decreased at 6 h,12 h,24 h and 48 h after operation,and experimental group were lower than those of control group(P＜0.05).The inflammatory response indexes[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]and stress response indexes[norepinephrine(NE),epinephrine(E)concentration,cortisol(Cor)]increased in two groups 1 d after operation,but experimental group were lower than those of control group at the same time(P＜0.05).The total incidence of adverse reactions in experimental group and con-trol group was 9.09％and 5.45％respectively,and there was no difference between two groups(P＞0.05).Conclusion:Compare with local infiltration anesthesia,ESPB can better control the hemodynamic stability of elderly patients undergoing PKP operation,reduce stress response and inflammatory response,and exert a good analgesic effect.
NETL
NSTL
万方数据
