Effect of Anesthesia with Esketamine and Propofol on Postoperative Pain and Serum Inflammatory Markers in Patients Undergoing Laparoscopic Cholecystectomy
Objective:To investigate the effect of anesthesia with esketamine and propofol on postoperative pain and inflammatory markers in patients undergoing laparoscopic cholecystectomy(LC).Methods:Eighty-four patients who were scheduled to undergo LC in the hospital from December 2021 to December 2023 were selected,and divided into a control group and an observation group using the random number table method,with 42 cases in each group.The two groups were given anesthesia induction with propofol and sufentanil,and anesthesia induction with propofol and esketamine,respectively.Perioperative related indicators in the two groups were observed.Ramsay sedation scores of the two groups when the patients entered the room(T0),after anesthesia induction(T1),at 10 min after the be-ginning of surgery(T2),at the end of surgery(T3),and when they were awake(T4)were analyzed.The Visual Analogue Scale(VAS)scores of the two groups at 1 h,6 h,12 h and 24 h after surgery were evaluated.Stress response indicators before surgery and at 24 h after surgery,and changes in inflammatory markers before surgery and on day 1 and day 3 after surgery were compared between the two groups.The incidence rates of adverse reactions in the two groups were calculated.Results:Comparison between the observation group and the control group found that wake-up time and PACU stay of the former group were shorter.The total dosage of propofol in the for-mer group was lower(P＜0.05).At T1 and T2,Ramsay sedation scores of the former group were higher.At T3,Ramsay sedation score of the former group was lower(P＜0.05).The levels of Cor,NE,and Glu in the former group were lower on day 1 after surgery(P＜0.05).The levels of CRP and IL-6 in the former group were lower on day 1 and day 3 after surgery(P＜0.05).The incidence rates of adverse reactions showed no significant difference between groups(P＞0.05).Conclusion:Anesthesia with esketamine and propofol can achieve good seda-tive effect on patients undergoing LC,which can reduce the dosage of anesthetics,promote postoperative recovery,inhibit inflammation and stress reaction,and alleviate postoperative pain.
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