Effects of Erector Spinae Plane Block Combined with Nalbuphine Preemptive Analgesia on Analgesic Effect,Immune Stress and Cognitive Function in Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer
Objective:To investigate the changes of analgesic effect,immune stress and cognitive function after preemptive anal-gesia with erector spinae plane block(ESPB)combined with nalbuphine in patients undergoing thoracoscopic radical resection of lung cancer.Methods:124 patients undergoing thoracoscopic radical resection of lung cancer were divided into control group(62 cases,ESPB)and study group(62 cases,ESPB combined with nalbuphine preemptive analgesia)according to the random number table method.The changes of postoperative analgesia pump pressing times,pain score,hemodynamic index,cellular immune function index,stress response index and cognitive function score were compared between two groups.Results:The number of postoperative analgesia pump pressing in study group was less than that in control group(P＜0.05).6 h,12 h,24 h and 48 h postoperative,visual analogue scale(VAS)scores of pain in study group were lower than those in control group(P＜0.05).The heart rate(HR)and mean arterial pressure(MAP)after catheterization,slicing and after extubation in study group were higher than those in control group(P＜0.05).The levels of CD3+,CD4+and CD4+/CD8+in study group were higher than those in control group at 24 h postoperative,CD8+,norepinephrine(NE)and epinephrine(E)in study group were lower than those in control group(P＜0.05).The scores of mini-mental state examination(MMSE)in study group were higher than those in control group at 24 h,48 h and 7 d postoperative(P＜0.05).Conclusion:ESPB combined with nal-buphine for preemptive analgesia in patients undergoing thoracoscopic radical resection of lung cancer,which can exert good analgesic effect,stabilize hemodynamics,reduce immune stress and affect cognitive function.
Erector spinae plane blockNalbuphinePreemptive analgesiaRadical resection of lung cancerAnalgesic effectIm-mune stressCognitive function
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