Effects of Dexmedetomidine Combined with Ultrasound-Guided Nerve Block on Postoperative Analgesia,Immune Stress and Pain Mediators in Patients with Hip Fracture Complicated with Diabetes
Objective:To observe the effects of dexmedetomidine combined with ultrasound-guided nerve block on postoperative analgesia,immune stress and pain mediators in patients with hip fracture complicated with diabetes.Methods:120 patients with hip frac-ture complicated with diabetes who were admitted to our hospital from June 2020 to June 2023 were divided into control group 60 cases(ultrasound-guided nerve block)and study group 60 cases(dexmedetomidine combined with ultrasound-guided nerve block)according to the random number table method.Postoperative patient-controlled intravenous analgesia(PCIA)was performed in both groups.The se-dation,analgesia,PCIA pressing times,immune function,stress response and pain mediators were compared between two groups,and the occurrence of adverse reactions during the treatment was observed.Results:12 h,24 h and 48 h after operation,the visual analogue scale(VAS)score in study group was lower than that in control group,and the Ramsay sedation score was higher than that in control group(P＜0.05).The number of PCIA compressions in study group was less than that in control group(P＜0.05).1 d after operation,CD3+,CD4+,CD4+/CD8+in study group were higher than those in control group,and cortisol(Cor),norepinephrine(NE),prostaglandin E2(PGE2),epinephrine(E),calcitonin gene-related peptide(CGRP),substance P(SP)and CD8+were lower than those in control group(P＜0.05).In terms of incidence of adverse reactions,there was no difference observed between the two groups in comparison(P＞0.05).Conclusion:Ultrasound-guided nerve block combined with dexmedetomidine in patients with hip fracture and diabetes,which can exert good sedative and analgesic effects,reduce immunosuppression and postoperative pain.
NETL
NSTL
万方数据
