The Application Effect of Different Administration Methods of Shunatracurium combined with Propofol in Laparoscopic Surgery and Its Impact on Muscle Relaxation and Recovery
Objective:To explore the application effect of different administration methods of cisatracurium combined with propofol in laparoscopic surgery and its impact on muscle relaxation and recovery.Methods:120 patients who underwent laparoscopic surgery in our hospital from January 2021 to November 2023 were selected.They were randomly divided into an intermittent medication group and a one-time medication group,with 60 patients in each group.All patients were treated with 2 mg/kg propofol,0.4 μg/kg sufentanil,and 0.5 µg/kg after entering the operating room.The intermittent administration group received intravenous injection of cisatracurium once every 2 hours,with a dose of 0.1 mg/kg.The one-time administration group received a single intravenous injection of 0.1 mg/kg cisatracurium to induce muscle relaxation,and the muscle relaxation effect was determined based on the T,seizure inhibition value,with T1=12％.When T1＞12％,intravenous injection of 0.03 mg/kg cisatracurium was administered.Compare the dosage,effective time of muscle relaxation,maintenance time of muscle relaxation,maximum inhibition of T1,onset time of muscle relaxation,baseline value upon entry(T1),immediate start of surgery(T2),20 minutes after surgery(T3),and immediate end of surgery(T4)in two groups of patients,as well as the changes in vital signs,recovery of postoperative muscle relaxation,and incidence of adverse reactions.Results:There was no significant difference in the maintenance time,T1 maximum inhibition program,and onset time of muscle relaxation between the two groups of patients(P＞0.05).The dosage of cisatracurium in the one-time treatment group was lower than that in the intermittent treatment group,and the effective time of muscle relaxation was higher than that in the intermittent treatment group(P＜0.05);There were no significant changes in heart rate(HR),systolic blood pressure(SBP),blood oxygen saturation(SPO2),and diastolic blood pressure(DBP)levels at T1,T2,T3,and T4 in the two groups of patients,and there was no significant difference between the one-time administration group and the intermittent administration group(P＞0.05);The TOFr 0.90,TOFr 0.80,TOFr 0.75,TOFr 0.25,and extubation time of patients in the one-time administration group were significantly lower than those in the intermittent administration group(P＜0.05);The incidence of adverse reactions such as bradycardia,rash,bronchospasm,and hypotension in the one-time administration group was significantly lower than that in the intermittent administration group(P＜0.05).Conclusion:Intermittent administration and one-time administration of cisatracurium in laparoscopic surgery have no significant impact on the patient's intraoperative vital signs,muscle relaxation maintenance time,and muscle relaxation effect.However,one-time administration and T,seizure inhibition value can reduce the dosage of cisatracurium administration,promote postoperative muscle relaxation recovery,and have high safety.
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