Relationship between Serum Lp-PLA2 and NT-3 Levels and Rapid Eye Movement Sleep Behavior Disorder in Patients with Parkinson's Disease
Objective:To investigate the relationship between serum lipoprotein-associated phospholipaseA2(Lp-PLA2),neu-rotrophin-3(NT-3)levels and rapid eye movement sleep behavior disorder(RBD)in patients with Parkinson's disease(PD).Methods:150 PD patients admitted to Zigong Hospital Affiliated to Southwest Medical University were selected as the PD group from January 2021 to December 2022,and at the same time,selected 55 healthy individuals who underwent physical examinations in our hospital as the control group.Enzyme linked immunosorbent assay(ELISA)was used to detect the serum levels of Lp-PLA2 and NT-3.The PD group was di-vided into RBD group and non RBD group based on the physical signs and RBD questionnaire Hong Kong version(RBDQ-HK)score.Univariate and multivariate logistic regression were used to analyze the influencing factors in PD patients concomitant with RBD,and the predictive efficacy of serum Lp-PLA2 and NT-3 in PD patients concomitant with RBD was analyzed by receiver operating characteristic curve(ROC)curve.Results:The serum Lp-PLA2 level in the control group was lower than that in the PD group(P＜0.05),and the serum NT-3 level was higher than that in the PD group(P＜0.05).The results of univariate analysis showed that the PD patients concomitant with RBD was associated with age,course of disease,and serum levels of Lp-PLA2 and NT-3(P＜0.05).Multivariate logistic regression analy-sis showed that prolonged course of disease,elevated Lp-PLA2 levels were independent risk factors for PD with RBD,while elevated NT-3 levels were protective factors for PD concomitant with RBD(P＜0.05).The area under the curve(AUC)of serum Lp-PLA2,NT-3,and combined detection for predicting PD concomitant with RBD were 0.830,0.766,and 0.866,respectively.Conclusion:Serum Lp-PLA2 and NT-3 are associated with PD patients concomitant with RBD.Elevated serum Lp-PLA2 is an independent risk factor,while elevated serum NT-3 is a protective factor.The combined detection of these two indicators has high predictive value for PD concomitant with RBD.
Parkinson's diseaseLipoprotein-associated phospholipaseA2Neurotrophin-3Rapid eye movement sleep behavior dis-order
NETL
NSTL
万方数据
