Relationship between Serum hs-CRP,CHIT1,midkine and Severity of the Disease and Visual Disability in Patients with Diabetic Retinopathy
Objective:To investigate the relationship between serum high-sensitivity C-reactive protein(hs-CRP),chitinase 1(CHIT1),mid-term factor(midkine)and severity of the disease and visual disability in patients with diabetic retinopathy(DR).Methods:198 type 2 DR patients admitted to our hospital from March 2021 to December 2022 were selected,according to the severity of the disease,patients were divided into non-proliferative DR and proliferative DR,the number of cases was 121 and 77 cases respectively,the levels of serum hs-CRP,CHIT1 and midkine in non-proliferative DR and proliferative DR were compared.The patients were followed up for 1 year in the form of outpatient review to observe the occurrence of visual disability in DR patients.The patients were divided into visual disability group and non-visual disability group,the number of cases was 31 cases and 167 cases respectively.The levels of serum hs-CRP,CHIT1 and midkine in visual disability group and non-visual disability group were compared,the risk factors of visual disability were analyzed by Logistic regression.Results:The levels of serum hs-CRP,CHIT1 and midkine in patients with proliferative DR were higher than those in patients with non-proliferative DR(P＜0.05).The levels of serum hs-CRP,CHIT1 and midkine in visual disability group were higher than those in non-visual disability group(P＜0.05).The results of univariate analysis showed that,visual disability in DR patients was not related to gender,age,intraocular pressure,fasting blood glucose(FPG),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and insulin resistance index(HOMA-IR)(P＞0.05),but related to the course of diabetes,the course of DR and glycosylated hemoglobin(HbAlc)(P＜0.05).Logistic regression analysis showed that,the longer the course of diabetes,the longer the course of DR,the higher hs-CRP,the higher CHIT1 and the higher midkine were the main risk factors for visual disability in DR patients(P＜0.05).Conclusion:The increase of serum hs-CRP,CHIT1 and midkine in DR patients are relate to the severity of the disease,and the visual disability of DR patients is affected by hs-CRP,CHIT1 and midkine,which is worthy of clinical attention.
Visual disabilityDiabetic retinopathyhs-CRPCHIT1MidkineSeverity of the disease
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