Relationship between Serum RVE1,CysC,SOCS1 Levels and Inflammatory Response,Thyroid Function and Th1/Th2 Cytokines in Patients with Hashimoto's Thyroiditis
Objective:To investigate the relationship between serum lysin El(RVE1),cystatin C(CysC),suppressor of cytokine signaling 1(SOCS1)and inflammatory response,thyroid function and Th1/Th2 cytokines in patients with hashimoto's thyroiditis(HT).Methods:121 patients with HT who were admitted to The First Affiliated Hospital of Air Force Military Medical University from July 2020 to October 2023 were selected as HT group,and 80 healthy subjects who underwent physical examination in our hospital of Air Force Military Medical University during the same period were selected as control group.The levels of serum RVE1,CysC,SOCS1 and inflammatory factors[C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),interleukin(IL)-12,IL-23],thyroid function indexes[thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)],Th1/Th2 cytokines[interferon-γ(IFN-γ),IL-4,IL-10]were compared between two groups,the correlation between serum RVE1,CysC,SOCS1 levels and inflammatory response,thyroid function,Th1/Th2 cytokines in HT patients were analyzed by Pearson correlation analysis.Results:Compared with the control group,the serum RVE1,FT3,FT4,IL-10 were lower,ESR,CRP,IL-12,IL-23,TSH,CysC,SOCS1,IFN-y,IL-4 were higher(P＜0.05).Pearson correlation analysis showed that,the levels of serum ESR,CRP,IL-12,IL-23,TSH,IFN-γ and IL-4 in HT patients were positively correlated with CysC and SOCS1(P＜0.05),negatively correlated with RVE1(P＜0.05).Serum FT3,FT4 and IL-10 levels were positively correlated with RVE1(P＜0.05),and negatively correlated with CysC and SOCS1(P＜0.05).Conclusion:Ababnormally decreased serum RVE1 levels and CysC and SOCS1 levels in HT patients are closely related to inflammatory response,thyroid dysfunction and immune function imbalance.
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