Study on the Relationship between the Expression of lncRNA HCG18 and miR-152-3p in Ovarian Cancer Tissues and Clinicopathological Features and Prognosis
Objective:To investigate the expression of long non-coding ribonucleic acids(lncRNA)human leukocyte antigen complex group 18(lncRNA HCG18)and microRNA-152-3p(miR-152-3p)in ovarian cancer tissues and their relationship with clinicopathological features and prognosis of patients.Methods:185 ovarian cancer patients admitted to our hospital from January 2016 to January 2021 were selected as the study subjects.The expression of lncRNA HCG18 and miR-152-3p in ovarian cancer tissues and adjacent tissues(≥ 2 cm from the edge of cancer tissues)were detected and compared by polymerase chain reaction(PCR).The relationship between the expression of lncRNA HCG18,miR-152-3p and the clinicopathological features of ovarian cancer patients was analyzed.Ovarian cancer patients were followed up for 3 years,the 3 years cumulative survival rate in ovarian cancer patients with high expression and low expression of lncRNA HCG18 and miR-152-3p were compared by Kaplan-Meier survival curve.The prognostic factors of ovarian cancer patients were analyzed by Cox risk model was used to analyze.Results:Comparison of the expression levels of lncRNA HCG18,ovarian cancer tissues was higher than that of adjacent tissues(P＜0.05),and Comparison of the expression levels of miR-152-3p,ovarian cancer tissues was lower than that of adjacent tissues(P＜0.05).The expression levels of lncRNA HCG18 and miR-152-3p in ovarian cancer tissues were related to International Federation of Gynecology and Obstetrics(FIGO)stage,degree of differentiation,ascites and lymph node metastasis(P＜0.05).The 3 years cumulative survival rate in high lncRNA HCG18 group was 41.57％(37/89),which was lower than 70.65％(65/92)in low lncRNA HCG18 group,there was a difference of statistical significance(P＜0.05).The 3 years cumulative survival rate in high miR-152-3p group was 75.53％(71/94),which was higher than 35.63％(31/87)in low miR-152-3p group,there was a difference of statistical significance(P＜0.05).Cox proportional hazard model analysis showed that,FIGO stage Ⅲ～IV,high and moderate differentiation,ascites,lymph node metastasis,lncRNA HCG18 increased,miR-152-3p decreased were risk factors for poor prognosis in ovarian cancer patients.Conclusion:The high expression of lncRNA HCG18 and the low expression of miR-152-3p in ovarian cancer tissues are relate to the occurrence of malignant clinicopathological features and poor prognosis.
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