Effects of Continuous Blood Purification and Intermittent Hemodialysis on RAAS System Indexes and Serum sTREM-1,HMGB1 and TLR4 in Patients with Sepsis Combined with Acute Kidney Injury
Objective:To compare the changes in serum renin angiotensin aldosterone(RAAS)system indicators and serum high mobility group protein 1(HMGB1),soluble myeloid cell trigger receptor-1(sTREM-1),and Toll like receptor-4(TLR4)levels in patients with sepsis complicated by acute kidney injury(AKI)after intermittent hemodialysis(IHD)and continuous blood purification(CBP)treatment.Methods:107 patients with sepsis combine with AKI admitted to our hospital from January 2019 to June 2023 were selected.Patients were divided into intermittent group(n=53,receiving IHD treatment)and continuous group(n=54,receiving CBP treatment)according to the random number table method.The RAAS system indexes,serum sTREM-1,HMGB1,TLR4,renal function and immune function indexes were compared between two groups.Results:After treatment,the renin activity(PRA),aldosterone(ALD),angiotensin I(AngI),sTREM-1,HMGB1,TLR4,urea nitrogen(BUN)and serum creatinine(Scr)in two groups decreased,and those in continuous group were lower than those in intermittent group(P＜0.05).After treatment,CD8+decreased in both groups,and continuous group was lower than than in intermittent group.CD3+,CD4+,CD4+/CD8+increased,and continuous group were higher than those in intermittent group(P＜0.05).Conclusion:Compared with IHD treatment,CBP treatment of sepsis combine with AKI,which can further improve renal function,improve immune function,regulate RAAS system indexes and serum sTREM-1,HMGB1,TLR4 levels.
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